Fantasy Football 2022: Week 6 Flex Rankings

It’s Wednesday, and that means it’s time to break out the fantasy football flex rankings for Week 6 of the 2022 NFL season. If you’re new to the concept of flex rankings, these are simply the combined overall rankings for running back, wide receiver and tight end for each week during the fantasy football season. These are not suggestions for who to start in your flex spots/

This list is our initial rankings, but it will change a lot throughout the week. If you want all the latest updates, then be sure to check our staff rankings page. Promo code “RATPACK” gets you 20% off of any FTN subscription.

Week 6 Flex Rankings (2022) – Top 100

1. Cooper Kupp vs. CAR (WR1) – He continues to roll and enters the week with a massive 64 targets.

2. Saquon Barkley vs. BAL (RB1) – Only Joe Mixon has touched the ball more than the 115 times Barkley has gotten his hands on the football this season. 

3. Nick Chubb vs. NE (RB2) – Chubb enters the week averaging a massive 6.05 yards per carry and leads all runners with 20 runs of 10-plus yards.

4. Justin Jefferson @MIA (WR2) – While he’s only scored twice, Jefferson leads the league in receiving yards with 547.

5. Stefon Diggs @KC (WR3) – He’s one of four players with over 500 receiving yards, and only Travis Kelce has more touchdowns.

6. Austin Ekeler vs. DEN (RB3) – Ekeler leads all players (including quarterbacks) in fantasy scoring over the last two weeks.

7. Jonathan Taylor vs. JAX (RB4) – Taylor should return this week after a one-game absence, but we aren’t out of the woods just yet.

8. Christian McCaffrey @LAR (RB5) – He leads all running backs with 35 targets through the first five weeks of the season.

9. Ja’Marr Chase @NO (WR4) – The fantasy numbers may not be popping right now, but Chase continues to see heavy work and averages over 10 targets per game.

10. Leonard Fournette @PIT (RB6) – Fournette is coming off a massive Week 5 and is one of just five running backs to see triple-digit touches so far this season.

11. Dalvin Cook @MIA (RB7) – He got things rolling last week and figures to see another big workload against the Dolphins.

12. Rhamondre Stevenson @CLE (RB8) – Damien Harris isn’t likely to play, positioning Stevenson as an RB1 in a plus matchup against a suspect Browns run defense.

13. Alvin Kamara vs. CIN (RB9) – This isn’t an ideal matchup, but Kamara is coming off a 29-touch game last week.

14. Tyreek Hill vs. MIN (WR5) – Hill got banged up last week, but we’re going to figure him right back up in Teddy Bridgewater’s revenge game.

15. Travis Kelce vs. BUF (TE1) – What do we get for an encore?

16. Joe Mixon @NO (RB10) – While the matchup is far from optimal, Mixon enters the week as the league-leader in touches with 116.

17. Aaron Jones vs. NYJ (RB11) – Despite the timeshare in the Packers’ backfield, Jones still ranks at RB12 on the season.

18. Mark Andrews @NYG (TE2) – He isn’t outscoring Travis Kelce, but Andrews has been pretty darn good this season.

19. Breece Hall @GB (RB12) – What’s that? Oh yes, Breece Hall is a top-10 fantasy scorer among running backs.

20. Mike Evans @PIT (WR6) – He’s scored three times this season and was extremely close to a fourth this past week.

21. Deebo Samuel @ATL (WR7) – Samuel is getting over four yards of separation on his targets. That’s tops among wideouts with over 30 targets on the season.

22. A.J. Brown vs. DAL (WR8) – He’s coming off a down week, but Brown still has a massive ceiling in this explosive Philly offense.

23. Jeff Wilson @ATL (RB13) – Wilson is coming off a big Week 5 and faces a Falcons defense that allows 4.7 yards per carry to opposing running backs.

24. Marquise Brown @SEA (WR9) – Over the last three weeks, Brown leads all receivers with 38 targets.

25. Miles Sanders vs. DAL (RB14) – The Eagles have fed Sanders 87 rushing attempts, which ranks fifth in the league.

26. CeeDee Lamb @PHI (WR10)

27. Mike Williams vs. DEN (WR11)

28. Kenneth Walker vs. ARI (RB15) – Expect a full workload for the rookie with Rashaad Penny now out for the season.

29. Jaylen Waddle vs. MIN (WR12)

30. DK Metcalf vs. ARI (WR13)

31. Courtland Sutton @LAC (WR14)

32. David Montgomery vs. WAS (RB16)

33. Melvin Gordon @LAC (RB17)

34. J.K. Dobbins @NYG (RB18)

35. Christian Kirk @IND (WR15)

36. Clyde Edwards-Helaire vs. BUF (RB19)

37. Najee Harris vs. TB (RB20) – The backslide continues for Harris as he gets yet another tough matchup.

38. Tee Higgins @NO (WR16)

39. Chris Godwin @PIT (WR17)

40. Tyler Lockett vs. ARI (WR18)

41. Gabe Davis @KC (WR19)

42. Michael Pittman vs. JAX (WR20)

43. James Robinson @IND (RB21)

44. Chris Olave vs. CIN (WR21) – Olave was concussed last week, so keep an eye on his status.

45. Amari Cooper vs. NE (WR22)

46. Terry McLaurin @CHI (WR23)

47. Devin Singletary @KC (RB22)

48. Diontae Johnson vs. TB (WR24)

49. Allen Lazard vs. NYJ (WR25)

50. Raheem Mostert vs. MIN (RB23) – Mostert solidified his status as the Dolphins’ RB1 and gets a top-10 matchup this week.

51. Eno Benjamin @SEA (RB24)

52. DeVonta Smith vs. DAL (WR26)

53. Kareem Hunt vs. NE (RB25)

54. Curtis Samuel @CHI (WR27)

55. Ezekiel Elliott @PHI (RB26)

56. Drake London vs. SF (WR28)

57. Zach Ertz @SEA (TE3)

58. Jakobi Meyers @CLE (WR29) – Meyers is trending up into WR3 territory after a big performance last week.

59. AJ Dillon vs. NYJ (RB27)

60. Travis Etienne @IND (RB28)

61. Dallas Goedert vs. DAL (TE4)

62. Adam Thielen @MIA (WR30)

63. Romeo Doubs vs. NYJ (WR31)

64. Jerry Jeudy @LAC (WR32)

65. Brandon Aiyuk @ATL (WR33)

66. Garrett Wilson @GB (WR34)

67. George Pickens vs. TB (WR35)

68. James Conner @SEA (RB29) – Conner is dealing with a ribs issue, so keep an eye on his status. If he can’t go, Eno Benjamin will be an RB2 play.

69. Cam Akers vs. CAR (RB30)

70. Tyler Higbee vs. CAR (TE5)

71. Devin Duvernay @NYG (WR36)

72. JuJu Smith-Schuster vs. BUF (WR37)

73. George Kittle @ATL (TE6)

74. DJ Moore @LAR (WR38)

75. Darnell Mooney vs. WAS (WR39)

76. Corey Davis @GB (WR40)

77. Tony Pollard @PHI (RB31) – The fact that Pollard is still buried behind Ezekiel Elliott keeps him down in flex territory. 

78. Isaiah McKenzie @KC (WR41)

79. Marquez Valdes-Scantling vs. BUF (WR42)

80. Tyler Allgeier vs. SF (RB32)

81. Tyler Boyd @NO (WR43)

82. Elijah Moore @GB (WR44)

83. Darrell Henderson vs. CAR (RB33)

84. Alec Pierce vs. JAX (WR45)

85. Rondale Moore @SEA (WR46)

86. Brian Robinson @CHI (RB34) – We aren’t using Robinson just yet, but the Commanders showed signs of a big role for him in his debut last week.

87. Michael Gallup @PHI (WR47)

88. Zay Jones @IND (WR48)

89. David Njoku vs. NE (TE7)

90. Michael Thomas vs. CIN (WR49)

91. Joshua Palmer vs. DEN (WR50)

92. Mike Boone @LAC (RB35)

93. Russell Gage @PIT (WR51)

94. Marvin Jones Jr. @IND (WR52)

95. Randall Cobb vs. NYJ (WR53)

96. Kyle Pitts vs. SF (TE8)

97. Allen Robinson vs. CAR (WR54)

98. Antonio Gibson @CHI (RB36)

99. Chase Claypool vs. TB (WR55)

100. K.J. Osborn @MIA (WR56)