Fantasy Football 2022: Week 10 Flex Rankings

It’s Wednesday, and that means it’s time to break out the fantasy football flex rankings for Week 10 of the 2022 NFL season. If you’re new to the concept of flex rankings, these are simply the combined overall rankings for running back, wide receiver and tight end for each week during the fantasy football season. These are not suggestions for who to start in your flex spots.

This list is our initial rankings, but it will change a lot throughout the week. If you want all the latest updates, then be sure to check our staff rankings page. Promo code “RATPACK” gets you 20% off of any FTN subscription.

Week 10 Flex Rankings (2022) – Top 100

1. Saquon Barkley vs. HOU (RB1) – He’s back from bye and gets one of the best matchups on the board.

2. Christian McCaffrey vs. LAC (RB2) – Ditto for McCaffrey. He was a monster before the bye and faces an extremely friendly Chargers run defense.

3. Tyreek Hill vs. CLE (WR1) – Hill has already topped 1,100 receiving yards on the season.

4. Derrick Henry vs. DEN (RB3) – He’s been steamrolling since Week 3 and will continue to see a heavy workload this week.

5. Cooper Kupp vs. ARI (WR2) – Despite the Rams’ offensive woes, Kupp continues to produce.

6. Justin Jefferson @ BUF (WR3) – This isn’t an easy matchup, but Jefferson’s enormous weekly ceiling keeps him in elite territory.

7. Austin Ekeler @ SF (RB4) – Ekeler has been unstoppable for fantasy purposes, but he gets one of the worst fantasy matchups of the week against a stout 49ers run defense.

8. Travis Etienne @ KC (RB5) – He has 20-plus carries in each of his last two games. 

9. Josh Jacobs vs. IND (RB6) – Jacobs has come back to earth in his last two contests, but gamescript sets up extremely well for him against a Colts team that is circling the drain.

10. Stefon Diggs vs. MIN (WR4) – Revenge game.

11. Davante Adams vs. IND (WR5) – It didn’t take long for Adams to bounce back. He remains a top-five fantasy wideout.

12. Travis Kelce vs. JAX (TE1) – Despite getting up there in age, Kelce is having yet another elite fantasy season.

13. A.J. Brown vs. WAS (WR6) – Brown put up five catches for 85 yards and a score against Washington in Week 3. He’s also scored five times in his last three games. 

14. Alvin Kamara @ PIT (RB7) – Last week wasn’t fun for Kamara managers, but his heavy volume and high ceiling keep him in the top 10.

15. Nick Chubb @ MIA (RB8) – Chubb enters the week averaging 5.6 yards per carry and has posted a league-leading 27 runs of 10-plus yards.

16. Kenneth Walker @ TB (RB9) – The rookie has scored seven rushing touchdowns over the last five weeks.

17. Dalvin Cook @ BUF (RB10) – This isn’t a good matchup for Cook, though it should be noted that the Bills have given up big days on the ground in each of the last two weeks.

18. DeAndre Hopkins @ LA (WR7) – We may see a shadow from Jalen Ramsey, but Hopkins is still going to get force-fed the football.

19. Dameon Pierce @ NYG (RB11) – He’s the only show in town in the Texans’ offense, and it’s a pretty darn good show.

20. Miles Sanders vs. WAS (RB12) – Sanders enters the week tied for seventh in the league with 131 rushing attempts.

21. Jaylen Waddle vs. CLE (WR8) – He doesn’t see as much volume as Tyreek Hill, but Waddle has still been excellent this season.

22. Amon-Ra St. Brown @ CHI (WR9) – This one sets up very well for St. Brown out of the slot.

23. Leonard Fournette vs. SEA (RB13) – Fournette is backsliding as the Bucs continue to use Rachaad White in a timeshare.

24. CeeDee Lamb @ GB (WR10) – This is a tough matchup, but Lamb will continue to be heavily-targeted this week.

25. Aaron Jones vs. DAL (RB14) – Early reports suggest Jones will play this week, but we’re far from out of the woods this week.

26. Jamaal Williams @ CHI (RB15)

27. Mike Evans vs. SEA (WR11)

28. Amari Cooper @ MIA (WR12)

29. Chris Olave @ PIT (WR13)

30. DK Metcalf @ TB (WR14)

31. Tyler Lockett @ TB (WR15)

32. Jonathan Taylor @ LV (RB16) – This is a placeholder ranking, as we don’t know if Taylor will be back this week. If he is, our expectations can’t be too high given the coaching shakeup in Indy.

33. Deebo Samuel vs. LAC (WR16)

34. David Montgomery vs. DET (RB17)

35. Christian Kirk @ KC (WR17)

36. Cordarrelle Patterson @ CAR (RB18)

37. JuJu Smith-Schuster vs. JAX (WR18) – Smith-Schuster has put up big fantasy numbers in his last three and has solidified his place as a WR2 fantasy option.

38. DJ Moore vs. ATL (WR19)

39. Chris Godwin vs. SEA (WR20)

40. Tony Pollard @ GB (RB19)

41. Najee Harris vs. NO (RB20)

42. James Conner @ LA (RB21)

43. D’Onta Foreman vs. ATL (RB22) – Expect the Panthers to use Hubbard along with Foreman Thursday night.

44. Allen Lazard vs. DAL (WR21)

45. Brandon Aiyuk vs. LAC (WR22)

46. Dallas Goedert vs. WAS (TE2)

47. Terry McLaurin @ PHI (WR23)

48. Gabe Davis vs. MIN (WR24)

49. Devin Singletary vs. MIN (RB23)

50. Jerry Jeudy @ TEN (WR25)

51. DeVonta Smith vs. WAS (WR26)

52. Joshua Palmer @ SF (WR27) – His ranking will move up significantly if Keenan Allen can’t return to the field.

53. Ezekiel Elliott @ GB (RB24)

54. Diontae Johnson vs. NO (WR28)

55. Raheem Mostert vs. CLE (RB25)

56. Michael Pittman @ LV (WR29)

57. D’Andre Swift @ CHI (RB26) – It’s tough to trust Swift as anything more than a flex option until his workload increases.

58. Courtland Sutton @ TEN (WR30)

59. Darnell Mooney vs. DET (WR31)

60. Curtis Samuel @ PHI (WR32)

61. George Kittle vs. LAC (TE3)

62. Adam Thielen @ BUF (WR33)

63. T.J. Hockenson @ BUF (TE4) 

64. AJ Dillon vs. DAL (RB27)

65. Zach Ertz @ LA (TE5)

66. Rondale Moore @ LA (WR34)

67. George Pickens vs. NO (WR35) – Having Chase Claypool out of the mix moves Pickens up into WR3 territory. 

68. Gerald Everett @ SF (TE6)

69. Drake London @ CAR (WR36)

70. Wan’Dale Robinson vs. HOU (WR37)

71. Antonio Gibson @ PHI (RB28)

72. Donovan Peoples-Jones @ MIA (WR38)

73. Brandin Cooks @ NYG (WR39)

74. Jeff Wilson vs. CLE (RB29) – He led the Dolphins’ backfield in snaps last week, but be careful to not get to overzealous with Wilson for fantasy purposes.

75. Khalil Herbert vs. DET (RB30)

76. Zay Jones @ KC (WR40)

77. Greg Dulcich @ TEN (TE7)

78. Michael Gallup @ GB (WR41)

79. Kareem Hunt @ MIA (RB31)

80. Taysom Hill @ PIT (TE8) – Hill was a fantasy dud last week, but he’s still capable of putting up top-10 tight end numbers given his multiple roles in the Saints’ offense.

81. Allen Robinson vs. ARI (WR42)

82. Terrace Marshall vs. ATL (WR43)

83. Mecole Hardman vs. JAX (WR44)

84. DeAndre Carter @ SF (WR45)

85. Keenan Allen @ SF (WR46)

86. Chase Claypool vs. DET (WR47)

87. Melvin Gordon @ TEN (RB32) – The timeshare remains in place in the Denver backfield, but Gordon is the preferred fantasy option.

88. Marquez Valdes-Scantling vs. JAX (WR48)

89. Darius Slayton vs. HOU (WR49)

90. Clyde Edwards-Helaire vs. JAX (RB33)

91. Kalif Raymond @ CHI (WR50)

92. Marvin Jones @ KC (WR51)

93. Tyler Allgeier @ CAR (RB34)

94. Pat Freiermuth vs. NO (TE9)

95. Mack Hollins vs. IND (WR52)

96. Robert Woods vs. DEN (WR53)

97. Kyle Pitts @ CAR (TE10)

98. Dalton Schultz @ GB (TE11)

99. Hunter Renfrow vs. IND (WR54)

100. Alec Pierce @ LV (WR55)