The Texas Rangers have placed outfielder Wyatt Langford (oblique) on the 10-day injured list due to a right oblique strain. The 23-year-old was removed from Tuesday's contest. He underwent an MRI on Wednesday, and due to the results, he will now be on the injured list. Fantasy managers should monitor his status as Langford dealt with an oblique injury earlier in spring training. On Wednesday, veteran Kevin Pillar will get the nod in left field and should see most of the opportunities while Langford sits out. After a modest rookie campaign, the Florida product was enjoying an impressive start to the 2025 season, hitting four home runs and holding a .244/.333/.561 slash line across 12 contests. In addition to Pillar, Dustin Harris or Ezequiel Duran could also have an increased role in the starting lineup.

San Diego Padres outfielder Fernando Tatis Jr. (shoulder) is not in the starting nine when the Padres conclude a three-game set against the Athletics. Tatis was lifted from Tuesday's contest due to discomfort in his left shoulder. This is the same shoulder he underwent surgery on during the 2022 campaign as well. Fantasy managers should keep an eye on his status leading up to their next contest on Friday evening against the Colorado Rockies. On Wednesday, Oscar Gonzalez will get the starting nod in right field and bat in the five-hole. Gonzalez would likely see most of the opportunities in the right field if Tatis misses an extended period of time. Through the first 12 games of the campaign, Tatis has enjoyed a strong start, holding a .364/.442/.523 slash line with two home runs. Gonzalez is not worth targeting in DFS, facing Osvaldo Bido, who enters this contest with a 2.70 ERA.

Cleveland Guardians outfielder Lane Thomas (wrist) is out of the starting lineup for Wednesday's game against the division-rival Chicago White Sox at Progressive Field after suffering a bruised right wrist when he was hit by a pitch in the team's home opener on Tuesday. X-rays came back negative on Thomas' wrist, so fantasy managers should consider him day-to-day for now. Check back to see if he's able to return to the lineup for the series finale against Chicago on Thursday. Nolan Jones will move to center field and bat sixth, while Jhonkensy Noel is starting in right field and hitting fifth on Wednesday against White Sox right-hander Sean Burke. Thomas has gone just 5-for-30 (.167) in the early going with two RBI and a steal, so perhaps the day off will do him well. Noel has similarly struggled with only one hit and an RBI in his first 17 at-bats of 2025. He's hitless in just one career at-bat against Burke.

After taking a day off on Tuesday, Seattle Mariners second baseman Jorge Polanco (side) is serving as the designated hitter and is batting second in Wednesday's series finale against the visiting Houston Astros and right-hander Hunter Brown at T-Mobile Park. Polanco has battled side soreness recently and was given the day off to rest on Tuesday, but he's back in there on Wednesday and will be hoping to keep his strong start to the 2025 season going. The 31-year-old Dominican infielder has 10 hits in his first 26 plate appearances of the season over seven games while delivering two home runs, 10 RBI, a stolen base, two runs scored, one walk and three strikeouts. Polanco continues to deal with injuries, though, and fantasy managers should probably expect the oft-injured switch-hitter to eventually land on the injured list. In eight career at-bats against Brown, Polanco is hitting .250 with a .625 OPS.

Baltimore Orioles infielder Jordan Westburg (upper body) is dealing with what manager Brandon Hyde called an "upper-body injury" and will get the day off on Wednesday in the series finale against the Arizona Diamondbacks at Chase Field. It's the same issue that prompted Hyde to sit Westburg for a game in Toronto on opening weekend. It's something to watch, but it doesn't sound very serious, so Westburg should be back in the starting lineup in Baltimore on Friday against the division-rival Blue Jays. Ramon Urias is starting at third and is batting eighth on Wednesday against D-backs right-hander Brandon Pfaadt. Since returning from his last day off with the upper-body injury, Westburg has gone just 5-for-30, although he does have three home runs in his first 11 games of the year. Urias will be a low-upside DFS play and he's never faced Pfaadt in his career.