Arizona Cardinals vs. San Francisco 49ers – Week 11 Betting Preview

The Arizona Cardinals will travel across the border to Mexico City to take on the San Francisco 49ers in Week 11 after both teams secured victories in Week 10. The Cardinals, with Colt McCoy at the helm, won the battle of the backups over the Rams who called up John Wolford to fill in for the concussed Matthew Stafford. They’ll go up in class this week against the 49ers’ offense that seemed to find its groove in the second half last week against the Chargers.

The 49ers have won two straight after getting trounced by the Chiefs in Week 7. After their victory in Week 10 and the Seahawks’ loss, San Francisco now sits just a half-game back in the NFC West and they’re projected to be favored in every game for the remainder of the season. Despite their 5-4 record, the 49ers also have the fourth-best odds to win the Super Bowl at FanDuel Sportsbook heading into Week 11.

When is Cardinals vs. 49ers Week 11?

Date/Time: Monday, Nov. 21, 8:15 p.m. ET
Stadium: Aztec Stadium, Mexico City
How to Watch: ESPN
Opening Odds: 49ers -7 | O/U 43.5

Week 11 Cardinals vs. 49ers Betting Odds

Here’s a look at the latest point spread and total for Sunday’s game.

Week 11 Cardinals vs. 49ers Stats to Know

• The Cardinals are 5-5 ATS this season, including 4-3 ATS as underdogs
• The 49ers are 4-5 ATS this season, including 3-4 ATS as favorites
• The under is 6-1 in the 49ers’ seven games as favorites
• The under is 4-3 in the Cardinals’ seven games as underdogs
• The 49ers and Cardinals are averaging a combined 50 points per game over their last three compared to 45 combined points per game for the season
• The Cardinals allow the most receiving yards per game to opposing tight ends
• The 49ers have the third best DVOA against the run in the NFL
• Christian McCaffrey has 15 targets in his last two games

Quarterback

Jimmy Garoppolo Prop Guide
Colt McCoy Prop Guide

Running Back

Christian McCaffrey Prop Guide
James Conner Prop Guide

Wide Receiver

Deebo Samuel Prop Guide
DeAndre Hopkins Prop Guide

Tight End

George Kittle Prop Guide
Trey McBride Prop Guide