Cleveland Guardians first baseman Josh Naylor is sitting out again on Wednesday against the hosting Baltimore Orioles. Naylor was also out of the starting lineup on Tuesday, but this time he'll take a seat against a right-handed pitcher in favor of rookie Jhonkensy Noel, who will be making his major-league debut against Orioles right-hander Grayson Rodriguez. There has been no word on a potential injury for Naylor, but fantasy managers may want to check back for more word on why the 27-year-old left-handed slugger is sitting out against a righty. Naylor has struggled against left-handed pitching this year, but overall he's been a force with 20 home runs, 58 RBI and 43 runs scored in his 274 at-bats while batting .241 (66-for-274). He's gone 19-for-74 (.257) with five homers, three doubles and 16 RBI in 19 games in June.

Los Angeles Angels infielder Brandon Drury (illness) will miss another game on Wednesday in the series finale against the visiting Oakland Athletics. Drury has been out for over a week now with an upper-respiratory illness and could land on the 10-day injured list if he's unable to play in the team's four-game weekend series against the visiting Detroit Tigers that begins on Thursday evening. For now, though, the 31-year-old veteran remains day-to-day. Along with a lot of the Angels players this year, Drury has had a miserable season between his production and his healthy. He's only had 110 at-bats and is currently hitting .173 with only one home run, six RBI and nine runs scored for the Halos. Luis Rengifo will handle second base on Wednesday and will bat in the two-hole against A's right-hander Joey Estes.

Philadelphia Phillies right-hander Spencer Turnbull (shoulder) left his start early on Wednesday against the Detroit Tigers with right-shoulder soreness after just 36 pitches in three innings, according to the team. Right-hander Taijuan Walker (finger) isn't eligible to come off the injured list until July 7, so Michael Mercado would likely be the next man up for the Phillies' starting rotation if Turnbull is forced to miss time. Mercado threw 91 pitches in back-to-back Triple-A starts on June 11 and 18. The 31-year-old Turnbull gave up an earned run on one hit while walking two and striking out two on Wednesday before departing with his injury. It's not a good sign that Turnbull was only able to throw 36 pitches in his first start since April 30, and he could be headed for a stint on the injured list.UPDATE: Turnbull felt "a little grab" in his right shoulder on his second-to-last pitch in the third inning. He'll undergo further evaluation on Thursday but didn't appear to be very concerned and joked that he can't seem to stay healthy in Detroit.

The Cleveland Guardians called up first base prospect Jhonkensy Noel from Triple-A Columbus on Wednesday and optioned outfielder Johnathan Rodriguez to Columbus in a corresponding move. With first baseman Josh Naylor missing a second straight game, Noel will make his major-league debut on Wednesday against the Baltimore Orioles and right-hander Grayson Rodriguez, starting at first base and batting sixth. The Guardians' No. 26 prospect, per MLB Pipeline, gets his first major-league call-up after hitting .295/.359/.578 with a .937 OPS, 18 home runs and 59 RBI in 65 games with Columbus. The 22-year-old right-handed hitter could get some run at first for the Guardians if Naylor is actually dealing with an injury. In addition to first base, Noel can also fill in at a corner-outfield spot if needed.

Milwaukee Brewers general manager Matt Arnold said that closer Devin Williams (back) could return from the 60-day injured list earlier than mid- to late-July. Williams is scheduled to throw a bullpen session on Wednesday for the first time since being shut down in spring training with multiple stress fractures in his back. The 29-year-old right-handed reliever will need multiple bullpen sessions and will also need to go on a minor-league rehab assignment, so there's no guarantee that he'll make his 2024 debut before the All-Star break in mid-July. Still, he's getting closer to game action and should be stashed in all fantasy leagues in the meantime. Once he's back up to speed, he'll eventually regain regular closing duties in Milwaukee. Until then, expect Trevor Megill to get most of the Brewers' save chances.