Tennessee Titans vs. Indianapolis Colts – Week 4 Betting Preview

The Tennessee Titans visit the Indianapolis Colts in a key Week 4 divisional matchup. The rivals were projected to be the top contenders for the AFC South title, but neither team finds itself in first place.

Tennessee held off the Las Vegas Raiders in Week 3 to pick up its first win of the 2022 season. Indianapolis did the same by upsetting the Kansas City Chiefs. The Colts are betting favorites to defeat the reigning AFC South champs. The loser of Sunday’s game in Indianapolis will face an uphill battle in trying to make the playoffs. 

Let’s take a look at some key statistics and information about this matchup.

When is Tennessee Titans vs. Indianapolis Colts Week 4? 

Date/Time: Oct. 2, 1 p.m. ET 
Arena: Lucas Oil Stadium
How to watch: FOX
Opening odds: Colts -3 | TEN +140, IND -170 | O/U 43

Week 4 Titans vs. Colts Betting Odds 

Here’s the latest point spread and total for Sunday’s game.

Week 4 — Titans vs. Colts Stats to Know 

(Use the FTN Bets Prop Shop to find the best odds for player prop bets)

• Colts and Titans are both 1-2 ATS
• Tennessee is 4-1 straight up against Indianapolis in the last five meetings
• Tennessee is averaging 34.7 points in the last three games against Indianapolis
• Colts are last in points per game (13.3)
• Colts have scored 20 points or fewer in five straight games
• Titans are 1-4 ATS in their last five games, including the playoffs
• All three Colts games have gone under the total
• Colts are 28th in yards per play (4.8)
• Titans lead the league red-zone touchdown percentage (85.7%)
• Titans are allowing the most yards per carry (5.8)
• Ryan Tannehill is averaging 215.7 passing yards, one touchdown and one interception per game
• Matt Ryan has been sacked the fourth-most times in the league (12)
• Robert Woods has fewer than 40 receiving yards in two of three games
• Michael Pittman is averaging 96.5 receiving yards per game
• Derrick Henry has rushed for at least 82 yards in two of three games
• Jonathan Taylor is fourth in the league in rushing yards per game (95.3)