San Francisco 49ers vs. Carolina Panthers – Week 5 Betting Preview

The San Francisco 49ers visit the Carolina Panthers as the biggest road favorites on the Week 5 schedule. The betting line increased by two points shortly after the 49ers defeated the Los Angeles Rams Monday night.

San Francisco has gone 2-1 since Jimmy Garoppolo replaced the injured Trey Lance at quarterback, looking more like the team that reached last season’s NFC Championship Game. The Baker Mayfield era is off to a poor start in Carolina. The Panthers are tied for the NFC’s worst record, led by one of the NFL’s most anemic offenses.

Let’s take a look at some key statistics and information about this matchup.

When is San Francisco 49ers vs. Carolina Panthers Week 5? 

Date/Time: Oct. 9, 4:05 p.m. ET 
Arena: Bank of America Stadium
How to watch: CBS
Opening odds: 49ers -4.5 | SF -200, CAR +170 | O/U 39

Week 5 49ers vs. Panthers Betting Odds 

Here’s the latest point spread and total for Sunday’s game.

Week 5 — 49ers vs. Panthers Stats to Know 

(Use the FTN Bets Prop Shop to find the best odds for player prop bets)

• Panthers are 1-3 straight up and ATS
• 49ers are 2-2 straight up and ATS
• Panthers and 49ers are a combined 1-7 to the under 
• Panthers are last in yards per game (262.3)
• 49ers are 24th in yards per game (324.5)
• Panthers are 26th in yards per pass attempt (6.4) and 14th in yards per carry (4.5)
• 49ers are first in opponents’ yards per play (3.8), yards per game (234.5) and points per game (11.5)
• 49ers have given up one offensive touchdown in the last three games 
• 49ers are tied for second in sacks (15)
• Jimmy Garoppolo has exactly one passing touchdown in six straight regular-season games
• Baker Mayfield has fewer than 200 passing yards in three straight games
• Deebo Samuel has at least 52 rushing yards or 73 receiving yards in all four games
• DJ Moore doesn’t have more than 50 receiving yards in a game this season
• Jeff Wilson has at least 74 rushing yards in three straight games
• Christian McCaffrey has at least 108 combined rushing and receiving yards in three straight games