Buffalo Bills DVOA, Stats, & NFL Rankings

Buffalo Bills running back James Cook (foot, toe) was unable to suit up for Friday's practice session. Cook hasn't been able to practice all week, which puts him on the wrong side of questionable ahead of the Week 6 matchup against the New York Jets. It's worth noting that the Bills do play on Monday, so Cook will get another chance to practice on Saturday. If he sits, Ty Johnson and Ray Davis would likely split up the workload in the backfield. Neither of them have done much of anything on the field this season. Davis has rushed 26 times for 75 yards, which is 2.9 yards per carry. Fantasy managers should consider Davis a shaky RB3 if Cook sits out.

Buffalo Bills wide receiver Curtis Samuel (foot/toe) was limited in Thursday's practice. Despite being limited, he was back on the field after missing Wednesday's practice. Samuel has been dealing with a foot/toe injury from a turf toe issue that has lingered since the preseason. This adds to a Bills injury report already crowded at the wide receiver position, with Khalil Shakir (ankle) and Mack Hollins (shoulder) also dealing with injuries. Samuel will have a few more chances to log a full practice to avoid an injury designation ahead of Monday's matchup with the New York Jets. The 28-year-old caught just one pass for zero yards in last week's loss to the Texans, despite his increased playing time. Samuel has been a non-factor in fantasy so far and is a dart throw (ranked WR70 at RotoBaller) at best in a tough matchup against the Jets in Week 6.

Buffalo Bills wide receiver Khalil Shakir (ankle) is not practicing on Thursday leading up to the Monday Night Football matchup against the New York Jets in Week 6. Shakir missed the Week 5 loss to the Houston Texans with an ankle injury, so he could reasonably sit out the AFC East contest. While the third-year wideout out of Boise State has not been a fantasy superstar this year, he's reached double-digit PPR points in all four active games, making him a solid flex option. Fellow wide receiver Curtis Samuel (foot) and receiving back James Cook (foot/toe) are also banged up, so Buffalo could have a depleted skill group. These injuries could clear the way for a big game from tight end Dalton Kincaid, but wideouts Keon Coleman and Mack Hollins will likely be more involved if at least two of the three banged-up pass-catchers can't suit up this week. However, the Jets have allowed the sixth-fewest fantasy points per game to receivers this year, so it could be an ugly passing attack for Buffalo on Monday night.

Buffalo Bills running back James Cook (foot, toe) is not practicing on Thursday after missing Wednesday's practice with foot and toe injuries. The third-year ball-carrier out of Georgia appears to be in real danger of missing the Week 6 game against the New York Jets, but the game is on Monday, so fantasy managers will need to stay tuned throughout the week. Cook has three weekly RB1 finishes in PPR leagues, so his absence could be a major problem for his managers. If he can't play, veteran Ty Johnson and rookie Ray Davis will likely share the backfield against a New York Jets defense that has surrendered the eighth-fewest fantasy points per game to running backs in 2024.

Buffalo Bills head coach Sean McDermott said that wide receivers Khalil Shakir (ankle) and Curtis Samuel (foot, toe) will not practice on Wednesday. Samuel's injuries were suffered in the Week 5 loss to the Houston Texans on Sunday, while Shakir was inactive for that game after being hurt the week prior. Shakir is the bigger name to follow for fantasy purposes. The 24-year-old didn't practice at all last week before being inactive, and another DNP to kick off the week isn't a great sign for his availability in Week 6, especially with a matchup against the division-rival New York Jets upcoming on Monday night. Buffalo's offense struggled without quarterback Josh Allen's top target available. Allen spread the ball around to rookie Keon Coleman, Mack Hollins, Samuel and Marquez Valdes-Scantling. Shakir's fantasy outlook remains very cloud this week, and if he does end up playing, he's eyeing a tough matchup against Jets corner Sauce Gardner.