Buffalo Bills DVOA, Stats, & NFL Rankings

After an up-and-down start to the season, Buffalo Bills quarterback Josh Allen (left hand) has thrown at least two touchdowns in his last four games. That could continue against the Indianapolis Colts on Sunday. The Colts' secondary has allowed 14 touchdown passes this season, which is good for ninth-most in the league. The Bills have also shifted to a more pass-happy approach to their offense. Allen's attempted 33, 34, and 39 passes in the last three games. Those attempts could decline if Amari Cooper (questionable, wrist) and Keon Coleman (out, wrist) aren't in the lineup on Sunday. As has been the case for the last several weeks, Allen's left hand injury is not keeping him from practicing. Allen is a high-end QB1, once again, against the Colts.

Buffalo Bills wide receiver Amari Cooper (wrist) has been tagged as questionable ahead of the Week 10 matchup against the Indianapolis Colts. The veteran wideout was unable to play last week due to the wrist issue, but appears to be trending towards playing this weekend. Cooper has been limited in practice all week, but that might just be the Bills being cautious with him. The Bills are already going to be without Keon Coleman (wrist) which means Cooper should have a bigger role. If active, Cooper should be a fine WR3 for this Week 10 matchup.

Buffalo Bills rookie wide receiver Keon Coleman (wrist) has been ruled out for Week 10, according to Katherine Fitzgerald of The Buffalo News. Coleman has been unable to participate in any practices this week after sustaining a wrist injury in last weekend's victory over the Miami Dolphins. In this game, the Florida State product caught just one pass for 21 yards. However, during Weeks 7 and 8, Coleman began to break out and averaged an impressive 97.5 yards per game during this stretch. In addition, other Buffalo wideouts Amari Cooper (wrist) and Curtis Samuel (pectoral) could also be in danger of missing this weekend's game, which could leave Khalil Shakir as the top option for quarterback Josh Allen.UPDATE: "It's a week-to-week deal," head coach Sean McDermott said. "It'll probably be multiple weeks."

Buffalo Bills wide receivers Curtis Samuel (pectoral) and Mack Hollins (shoulder) were both wearing non-contact jerseys at Thursday's practice session. Hollins was listed as a full participant on Wednesday, so this would represent a downgrade for him. Samuel returned in the Week 9 win over the Miami Dolphins after missing Week 8, but he failed to catch his only target with Amari Cooper (wrist) out and has gone without a catch in each of his last two games. Rookie Keon Coleman (wrist) might miss multiple weeks, but even with Buffalo's receivers beat up, Samuel isn't an attractive starting fantasy lineup option. Hollins had gone without a catch in each of his last two games before bringing in all five of his targets for 30 yards and a touchdown in Week 9. If Cooper is out again this weekend, Hollins will be a touchdown-dependent WR4/flex option, at best, in deeper leagues.

ESPN's Alaina Getzenberg reports that Buffalo Bills wide receiver Amari Cooper (wrist) is practicing in a similar fashion to last week. Cooper was inactive for the Week 9 win over the division-rival Miami Dolphins but was limited in Wednesday's walkthrough. He's likely to be listed as limited for a second straight day on Thursday and is up in the air to play in Week 10 versus the Indianapolis Colts. With rookie Keon Coleman (wrist) possibly missing multiple weeks with his own wrist injury, look for Khalil Shakir to see increased volume against the Colts, especially if Cooper misses a second straight game. The 33-year-old Cooper had four catches for 66 yards and a touchdown in his Bills debut in Week 7 before getting injured in Week 8. If Cooper is able to get the green light to return this Sunday, he should be considered a must-start for fantasy managers.UPDATE: Cooper was limited again Thursday.