Jacksonville Jaguars vs. Indianapolis Colts – Week 2 Betting Preview

After a disappointing performance in Week 1 that resulted in a tie against the Houston Texans, the Indianapolis Colts will look to bounce back on the road against the AFC South’s other projected cellar-dweller, the Jacksonville Jaguars.

The Jags lost a tightly contested game in Washington at the hands of the Commanders, but they may have had more positive takeaways from Week 1 than the Colts. Indianapolis entered the season with their sights set on a division championship, so they’ll need to rebound strongly to ensure they don’t fall behind in one of the league’s weakest divisions.

When is Jacksonville Jaguars vs. Indianapolis Colts Week 2?

Date/Time: Sunday, Sept. 18, 1 p.m. ET
Stadium: EverBank Field
How to Watch: CBS, Paramount+
Opening Odds: Colts -4.5 | O/U 45.5

Week 2 Jaguars vs. Colts Betting Odds

Here’s a look at the latest point spread and total for Sunday’s game.

Week 1 Jaguars vs. Colts Stats to Know

• The Colts are 6-3 ATS in their last nine games on the road
• The Colts are 6-3-1 straight up in their last 10 games as favorites
• The Jaguars went 2-0 ATS against the Colts in 2021
• The Jaguars are 5-11 ATS in their last 16 games as an underdog
• The UNDER is 7-2 in the Colts’ last nine games as favorites
• The UNDER is 12-4 in the Jaguars’ last 16 games as underdogs
• Matt Ryan’s O/U is 236.5 passing yards – he’s gone UNDER that number in 6 of his last 8 games
• Trevor Lawrence’s O/U is 247.5 passing yards – he’s gone UNDER that number in 10 of his last 12 games
• Jonathan Taylor’s O/U is 99.5 rushing yards – he’s gone OVER that number in 8 of his last 10 games
• Michael Pittman’s O/U is 61.5 receiving yards – he’s gone OVER that number in 4 of his last 6 games