Buffalo Bills vs. Kansas City Chiefs – Week 6 Betting Preview

Nine months after meeting in one of the greatest playoff games of all time, the Buffalo Bills and Kansas City Chiefs are set to do battle again. The Chiefs outlasted the Bills 42-36 in their overtime thriller, but Buffalo is the betting favorite on the road in Week 6.

Patrick Mahomes is a home underdog for the first time in his career as the Chiefs starting quarterback. Buffalo defeated Kansas City 38-20 in Week 5 of last season. Ahead of Sunday’s game, the two teams are tied for the best record in the AFC. They are the top two scoring teams in football and have the best odds to win Super Bowl 57. 

Let’s take a look at some key statistics and information about this matchup.

When is Buffalo Bills vs. Kansas City Chiefs Week 6? 

Date/Time: Oct. 16, 4:25 p.m. ET 
Arena: Arrowhead Stadium
How to watch: CBS
Opening odds: Bills -1.5 | BUF -125, KC +105 | O/U 54

Week 6 Bills vs. Chiefs Betting Odds 

Here’s the latest point spread and total for Sunday’s game.

Week 6 — Bills vs. Chiefs Stats to Know 

(Use the FTN Bets Prop Shop to find the best odds for player prop bets)

• Chiefs are 6-2 straight up and 7-0-1 ATS as underdogs when Patrick Mahomes starts
• Buffalo’s league-best point differential (+91) is 44 points better than any team in the league 
• Chiefs lead the league in points per game (31.8) 
• Bills are second in points per game (30.4) and rank first in both yards per play (6.7) and yards per game (440.4)
• Chiefs have scored at least 27 points in four of five games
• Bills haven’t given up more than 21 points in a game this season
• Bills are tied for first in points allowed per game (12.2) and rank second in both opponents’ yards per play (4.4) and opponents’ yards per game (260.4)
• Bills are tied for most interceptions (8) and Chiefs are tied for second-fewest interceptions (1) 
• Josh Allen is first in passing yards per game (330.2) and has at least 42 rushing yards in four of five games
• Patrick Mahomes is first in passing touchdowns (15) and has at least three touchdown passes in six of the last eight games, including the playoffs
• Stefon Diggs has more than 100 receiving yards in three of five games
• Travis Kelce leads the league in receiving touchdowns (7)
• Devin Singletary has fewer than 50 rushing yards in all five games this season
• Clyde Edwards-Helaire is averaging 44.6 rushing yards per game