Arizona Cardinals vs. Seattle Seahawks – Week 6 Betting Preview


The Arizona Cardinals visit the Seattle Seahawks in an NFC West matchup on the Week 6 schedule. The losing team will fall to 2-4 and occupy last place in the division.


The Cardinals are favored on the road, even though the team has been far from impressive to start the 2022 season. Both of Arizona’s victories have come against teams that enter Week 6 with a 1-4 record. Geno Smith has been a pleasant surprise as Russell Wilson’s replacement in Seattle. The Seahawks just lost Rashaad Penny for the season because of a broken leg.

Let’s take a look at some key statistics and information about this matchup.

When is Arizona Cardinals vs. Seattle Seahawks Week 6? 

Date/Time: Oct. 16, 4:05 p.m. ET 
Arena: Lumen Field
How to watch: FOX 
Opening odds: Cardinals -2.5 | AZ -140, SEA +120 | O/U 50

Week 6 Cardinals vs. Seahawks Betting Odds 

Here’s the latest point spread and total for Sunday’s game.


Week 6 — Cardinals vs. Seahawks Stats to Know 

(Use the FTN Bets Prop Shop to find the best odds for player prop bets)

  • Arizona is 3-2 straight up against Seattle in the last five meetings
  • Cardinals are 2-0 straight up and ATS on the road
  • Seahawks are 1-3 straight up and ATS in the last four games
  • Seahawks are 3-0 to the over in the last three games with an average of 74.7 total points in each contest
  • Cardinals haven’t scored more than 26 points in regulation 
  • Seahawks are second in yards per play (6.6)
  • Seahawks are last in yards allowed per play (6.6) and yards allowed per game (430.0)
  • Cardinals are fifth in rushing yards allowed per game (97.4)
  • Seahawks have given up at least 27 points in four straight games
  • Geno Smith has the league’s highest passer rating (113.1)
  • Kyler Murray is averaging 248.2 passing yards per game
  • Tyler Lockett has more than 90 receiving yards in three of the last four games
  • Marquise Brown has at least 78 receiving yards in three straight games
  • Kenneth Walker is averaging 6.3 yards per carry
  • James Conner has exactly 55 rushing yards in two straight games
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