Baltimore Orioles second baseman Jackson Holliday and outfielder Colton Cowser are out of the Orioles lineup on Saturday against Kansas City Royals lefty Cole Ragans. Holliday has had a rough start to his MLB career, hitting for a .037 batting average in 28 PA. Cowser has been Baltimore's best hitter, on the other hand, posting a 1.178 OPS in 51 PA. Austin Hays will get the start in left field for Cowser. Jordan Westburg will slide over from third base to second base and Ramon Urias will start at third. Both Holliday and Cowser should be expected to be back in the lineup on Sunday against Royals right-hander Seth Lugo.

Minnesota Twins third baseman Royce Lewis (quadriceps) has started to begin baseball activities according to the Twins head trainer Nick Paparesta. "We're looking to get him in a running progression probably the end of next week. He's still got some boxes to check, but heading in the right direction," the trainer said. No timetable has been set for the 24-year-old's return though it's still likely he won't be back until closer to the All Star Break. Kyle Farmer and Jose Miranda have been splitting time at third base in Lewis' absence. Farmer has hit for a paltry 15 wRC+ in 41 PA while Miranda has hit for a 119 wRC+ in 28 PA. Fantasy managers shouldn't rush to add either player in Lewis' absence, though Miranda shows more potential currently.

Houston Astros starting pitcher Framber Valdez (elbow) threw a bullpen session on Saturday. This marks the first time Valdez has thrown off of a mound since he was put on the injured list. The Astros will wait to see how the lefty responds to the bullpen session before taking next steps, though there is a chance he will be activated without needing a rehab start. The Astros are desperate for his return as their staters have posted a 4.93 ERA to begin the season, 5th worst in the majors. The lefty posted a 2.19 ERA in his two starts before hitting the injured list so his return will provide a boost to the Astros, who also welcomed back Justin Verlander on Friday. Fantasy managers will want to keep an eye on Valdez's progress in the event a rehab assignment isn't necessary.

Cincinnati Reds infielder Jeimer Candelario (illness) is back in the starting lineup Saturday against the visiting Los Angeles Angels and left-hander Patrick Sandoval. The veteran has been out since being scratched from Tuesday's contest with an illness, but he appears to be feeling better and will man the hot corner and hit cleanup against the southpaw on Saturday. It's been a slow start to the season for the 30-year-old, who is hitting just .190 with a couple of homers and a .649 OPS across his first 64 trips to the plate after he set career-highs with 22 homers and eight stolen bases across 140 games between the Nationals and Cubs in the 2023 campaign.

Pittsburgh Pirates right-hander Mitch Keller will look to keep up the good work in a Saturday outing versus the visiting Boston Red Sox. After allowing four earned runs in each of his first two starts of the season, the 28-year-old has allowed just two earned runs in each of his last two starts and 13 innings of work. He has 13 strikeouts against just four walks in that time and did not walk a batter across seven innings his last time out. Fantasy managers should certainly be encouraged by his start to the season, even if his 19.8% K% leaves something to be desired as he posted a 25.5% K% last season alongside a healthy 18.8% K-BB%. He should see continued positive ERA regression moving forward as his 3.87 xFIP and 4.09 SIERA sit well below his 4.50 ERA on the young season.