Houston Astros right-hander Hayden Wesneski won't make his next start until potentially early next week in Milwaukee against the Brewers. Wesneski will have extra time between starts with right-hander Lance McCullers Jr. (forearm) coming off the 15-day injured list to make his 2025 debut this Sunday against the Chicago White Sox. The 27-year-old Wesneski had no walks and only one strikeout in five innings of work (two earned runs) in his last outing on April 25 against the Kansas City Royals for his second loss of the season. It wasn't a terrible outing, but Wesneski definitely wasn't as sharp as he was in his first four starts for Houston. Hopefully the extra rest will end up working out well for the former Chicago Cub, but the matchup will be a tough one on the road against the Brew Crew. Wesneski has a 3.86 ERA and 1.00 WHIP with 26 K's in 28 innings over his first five starts in 2025.

Houston Astros right-hander Lance McCullers Jr. (forearm) will make his 2025 season debut on Sunday in Chicago against the White Sox, according to the Houston Chronicle's Matt Kawahara. It's an excellent matchup for his season debut, but fantasy managers need to remember that this will be McCullers' first big-league start since the World Series in 2022. The 31-year-old veteran started facing live hitters back in February and posted a 2.84 ERA and 1.26 WHIP with 16 strikeouts and six walks in four minor-league rehab starts over 12 2/3 innings with Double-A Corpus Christi and Triple-A Sugar Land. He threw five scoreless innings over 71 pitches in his final rehab start last Saturday, so he should be built up to go fairly deep this weekend. McCullers was fantasy relevant in all leagues before his forearm injuries set in, but his upside could be limited as the Astros handle him carefully.

Arizona Diamondbacks shortstop Geraldo Perdomo and infielder/outfielder Pavin Smith will both start on the bench on Wednesday against the hosting New York Mets. It will be Perdomo's first day off this season. Garrett Hampson is starting at the 6 and batting ninth, while Randal Grichuk will serve as the designated hitter and bat third against Mets right-hander Huascar Brazoban. Left-hander Brandon Waddell is scheduled for a bulk-relief role, which is why Arizona is resting both Perdomo and Smith, who both hit left-handed. Perdomo has struggled of late, going 5-for-36 with a homer, two doubles, two RBI, three steals, si walks and six K's in his last nine games. Smith has been hot in the first month, slashing .347/.478/.639 with four homers, nine RBI and 16 runs scored. Grichuk has a hit in just two career at-bats against Brazoban.

New York Mets outfielder Brandon Nimmo (illness) remains out of the starting lineup for Wednesday's contest against the Arizona Diamondbacks at Citi Field. Nimmo had a career day with two home runs and a whopping nine RBI in Monday's victory over the D-backs but then came down with an illness and is sitting out a second straight game. Fantasy managers will have to check back to see if the 32-year-old veteran is feeling good enough to play in Thursday's series finale. Jeff McNeil will start in left field on Wednesday and bat sixth against Diamondbacks right-hander Corbin Burnes. McNeil got off to a late start this year due to an oblique injury and has gone 4-for-12 with a homer and three RBI in his first three games. He's hit .267 with a homer and two RBI in 15 career at-bats against Burnes but will be a poor DFS choice in this matchup on Wednesday.

Miami Marlins outfielder Griffin Conine (shoulder) is expected to miss the rest of the 2025 season after undergoing left-shoulder surgery in Los Angeles on Tuesday, according to the Miami Herald's Barry Jackson. The good news is that Conine will be ready for the start of spring training next year. The 27-year-old dislocated his left shoulder earlier in April while sliding into second base and will now miss the rest of the campaign after starting off the year hot with a .281 average (18-for-64) with a home run, seven RBI and 10 runs scored in 20 games played. He has now slashed .274/.338/.445 with an above-average .783 OPS, four homers and 19 RBI the last two years for the Fish in just 50 games. If he's fully healthy to begin next season, he should be a lineup regular for the Marlins in 2026. Jesus Sanchez and Kyle Stowers have been manning right field for Miami since Conine went down.