Seattle Mariners shortstop J.P. Crawford is hitting in the leadoff spot for Wednesday's series finale against the division-rival Los Angeles Angels and left-hander Tyler Anderson at T-Mobile Park. Crawford has made it all the way up to leadoff this week after hitting in the nine-hole in his first 26 starts of 2025. The Mariners moved him up to sixth the previous two games. The 30-year-old veteran has earned the move up the batting order, as he carries an eight-game hitting streak into Wednesday's finale against the Halos. During the streak, he's gone 12-for-29 with two home runs, eight RBI, seven runs scored and five walks to raise his season line to .279/.415/.372 in 108 plate appearances. It remains to be seen how long Crawford will get run in the top spot, but it will make him more attractive in DFS on Wednesday, even against a lefty. He's hit .273 with two RBI in 11 career at-bats against Anderson.

Seattle Mariners second baseman/designated hitter Jorge Polanco is out of the starting lineup with a left-hander on the mound on Wednesday in the series finale against the division-rival Los Angeles Angels. Catcher Cal Raleigh is serving as the DH and is batting third, while Mitch Garver is catching and hitting fifth against Angels left-hander Tyler Anderson. Polanco has only been able to hit from the left side in games recently due to a minor side injury, so he'll take a seat in this one despite hitting two home runs and driving in five in the win on Tuesday. The 31-year-old Dominican switch-hitter has been raking in his first 72 at-bats in 2025, slashing .389/.423/.819 with nine homers, 25 RBI and 12 runs scored. Fantasy managers will want to get him back in their lineups immediately when he returns to face a right-hander. Raleigh has a homer and three RBI in 10 career at-bats versus Anderson.

The Houston Astros have placed relief pitcher Bryan Abreu on the paternity list. As a result, AJ Blubaugh will take his spot on the roster. Through the early part of the campaign, Abreu has been deployed in his typical setup role in front of the ninth-inning option, Josh Hader. Across 13 innings of work, Abreu has held a strong 2.08 ERA with a 1.46 WHIP. Abreu has tallied nine holds and struck out 18 batters. Under the hood, he generated an elite 2.9 percent barrel rate while generating whiffs at a strong 34.0 percent rate. While he is sidelined for the time being, Taylor Scott, Bryan King, or Kaleb Ort should see time in the eighth inning. When he is cleared to return, Abreu will remain a top option in leagues that reward holds, given his high strikeout potential.

Los Angeles Angels outfielder Taylor Ward is getting his first day off on Wednesday afternoon when the Angels face the Seattle Mariners. Ward has gone 0-for-13 with a 5:2 K:BB over his last four games and will get a day to reset. As a result, Gustavo Campero will get the nod in left field and bat in the seven-hole. Infielder Zach Neto will move up to the leadoff spot with Ward sitting out. However, before this slump, Ward held a modest .231/.259/.577 slash line with three doubles and five home runs over his last 13 games. Fantasy managers should expect Ward to return to the starting nine on Thursday when they begin a series against the Detroit Tigers. This afternoon, the Angels are worth targeting in DFS, facing the Mariners, who will send Emerson Hancock to the mound, who enters this game with a 7.71 ERA.

The Toronto Blue Jays are promoting left-handed pitcher Eric Lauer from Triple-A Buffalo prior to their contest on Wednesday against the Boston Red Sox. Lauer was slated to start for Triple-A this evening. Fantasy managers should monitor his status leading up to this game as he may be given the starting nod or could be deployed in a bulk relief role. Through 24 innings at Triple-A this season, the left-hander has held a modest 4.50 ERA with a 1.25 WHIP. During this stint, he has struck out 21 batters and served up six free passes. Last season, Lauer spent time in Milwaukee and logged a high 6.56 ERA and a 1.67 WHIP across 46 2/3 innings of work. He generated a 7.54 xERA with a .307 xBA, which were both in the first percentile. If he gets the starting nod, he should not be targeted in DFS formats.