Athletics outfield prospect Colby Thomas has had a solid start to the Triple-A campaign, slashing .276/.364/.460 with three home runs, 13 RBI, 16 runs scored, and two stolen bases through 22 games. The former third-round draft pickhas been swinging the bat particularly well over the last 10 contests, going 13-for-44 (.295), so he could be the next big prospect call-up for the A's in the coming months. Their second-ranked prospect showed well at Triple-A last season as well, slashing .272/.344/.559 with 17 home runs in 73 games (14 at Double-AA, too), and appears to be ready to make the next jump. Managers in AL-only leagues in need of a power boost could consider stashing the 24-year-old ahead of his eventual call-up, which is likely to happen around midseason.

Minnesota Twins outfield prospect Emmanuel Rodriguez has had an inconsistent start to the 2025 campaign, logging five multi-hit performances and eight hitless efforts over his first 17 games, resulting in an uninspiring.231 AVG with no home runs and a 34.6 percent strikeout rate. A bright spot has been the Dominican's ability to draw walks, logging 13 of them thus far (16.7 percent). The Twins' second-ranked prospect (MLB No. 34) is expected to make his major league debut this season, but has played just 24 games at Triple-A, without much success. If the left-handed slugger can get on a roll, look for a call-up around midseason, especially with Minnesota's offense sputtering and in need of a boost.

New York Mets infielder Jeff McNeil is starting at second base and is hitting eighth in his 2025 season debut on Friday against the division-rival Washington Nationals and right-hander Jake Irvin. McNeil was activated from the injured list on Thursday night and will make his first start for the Mets this year after missing the first four weeks of the year due to a right-oblique strain. The 33-year-old former batting champion went 11-for-28 (.393) with two home runs and three RBI in his eight minor-league rehab games with Single-A St. Lucie, Double-A Binghamton and Triple-A Syracuse. He will see most of his starts at the keystone in New York, but fantasy managers in 12-team leagues will want to see more from McNeil after he hit just .238 with 12 homers and 44 RBI in 129 games a year ago. In seven career at-bats against Irvin, he's hit .143 with a .393 OPS.

Baltimore Orioles third base prospect Coby Mayo has gotten going after a 3-for-24 (.125) start to the season, now 16-for-54 (.296) over the last 14 contests, including five doubles, a triple, and three home runs with a 10:16 BB:K over that stretch. Mayo had a brief, disappointing stint with the O's last year, going 4-for-41 (.098) in his 17-game audition. The results should be betterthe next time around, which should happen around midseason, so long as he continues to hit. The 6-foot-4 slugger offers a big-time power stroke with a solid eye, so he could be an impactful fantasy contributor once he's a mainstay in the big leagues. The Orioles' second-ranked prospect could be a stash candidate in deep leagues if it looks like he's getting closer to a promotion.

St. Louis Cardinals second baseman Brendan Donovan (rib) is back at second base and is hitting third for Friday's series opener at Busch Stadium against the division-rival Milwaukee Brewers and right-hander Chad Patrick. Donovan will return to the lineup after missing the last two games earlier this week after one of his ribs popped out of place. It sounds playful, but the 28-year-old utility man is ready to go for the weekend series against Milwaukee and should be returned to fantasy lineups. Although the German infielder/outfielder has never faced Patrick, he's been one of the most productive hitters through the first month of the 2025 season. Donovan enters Friday's game slashing .356/.392/.533 with a .925 OPS, three homers, 13 RBI, 14 runs scored and three stolen bases. He's not going to give you much power, but fantasy managers need to ride his hot streak while it lasts.