Tampa Bay Rays infielder Isaac Paredes and outfielder/designated hitter Harold Ramirez are not in the team's starting lineup on Wednesday against the hosting Milwaukee Brewers. Curtis Mead is starting at third base and batting ninth, while Yandy Diaz is the designated hitter and batting leadoff against Brewers right-hander Colin Rea. Austin Shenton is at first base and is hitting fifth. Paredes will take a seat after starting each of the team's last 11 games. The 25-year-old has been a solid fantasy contributor with a .291/.358/.509 slash line, an .867 OPS, seven home runs and 17 RBI in 110 at-bats. Ramirez will be on the bench for the third time in the last five games and is losing playing time while going 27-for-106 (.255) to open the year with a homer, 10 RBI and three steals. With Jonathan Aranda's (finger) return on the horizon, Ramirez's fantasy stock could plummet even further.

Tampa Bay Rays manager Kevin Cash said that outfielder Jose Siri (thigh) is out of Wednesday's starting lineup due to soreness in his left thigh that stems from him being hit by a pitch in Tuesday's game. It was an eventful day for Siri on Tuesday, as he hit his second home run of the season and was also ejected after throwing blows with Milwaukee Brewers relief pitcher Abner Uribe in a benches-clearing incident. Fantasy managers should expect the 28-year-old to be handed down a suspension of at least a couple games in the near future. Despite going 1-for-2 with the home run on Tuesday, Siri is hitting just .186 (16-for-86) on the year with seven RBI and six stolen bases through the first month of the year. Randy Arozarena is in center field and batting third, while Niko Goodrum is in left and hitting sixth on Wednesday against Brewers right-hander Colin Rea.

Baltimore Orioles infield prospect Jackson Holliday went 3-for-6 with two singles and a double during his Triple-A appearance on April 30. The top prospect in baseball also drove in one run, scored twice, and logged two strikeouts. Holliday put together an elite start to the minor league season and earned a promotion to the majors in the middle of April. However, he struggled tremendously in Baltimore, going 2-for-34 with 18 strikeouts over his first 10 games. The Orioles sent him back to Triple-A Norfolk, and he's gone 4-for-14 in three games since his demotion. Even if Holliday goes on another tear, the Orioles may decide to be extra patient before calling him back up to the majors given how he struggled during his first taste of big-league action. Plus, it's not like the Orioles have a shortage of minor-league talent. Third baseman Coby Mayo has arguably been even more productive than Holliday, so he could be the next prospect to get the call.

Baltimore Orioles third base prospect Coby Mayo went 2-for-4 with a single and three-run homer at the Triple-A level on April 30. He also struck out once and drew a pair of walks. Baltimore seems to have a surplus of hot-hitting prospects and Mayo might be the next to make his MLB debut. He's making a strong push for a promotion with his .330/.400/.652 slash line, nine home runs, and 25 RBI through 28 games this year. He has now homered in back-to-back games and also owns a four-game hitting streak.

Cleveland Guardians first base prospect Kyle Manzardo went 2-for-5 with a double and solo homer on April 30. He currently owns a three-game hitting streak and has ultimately got on base in five consecutive contests. The 23-year-old left-hander has already launched seven homers this year, and he owns a strong .991 OPS. Furthermore, he's maintained a 12.7 BB% and 17.3 K%, both impressive marks for someone with significant power. Manzardo was dealt from Tampa Bay to Cleveland last summer and is now pushing hard to make his MLB debut this May.