Tennessee Titans vs. Buffalo Bills – Week 2 Betting Preview


The Tennessee Titans visit the Buffalo Bills in a Week 2 matchup between last season’s AFC No. 1 seed and this year’s Super Bowl favorite. The Bills are 10-point favorites at most sportsbooks.


Buffalo managed to exceed sky-high expectations in the NFL’s Kickoff Game, defeating the defending champion Los Angeles Rams 31-10 on the road. Tennessee’s first game didn’t provide much optimism for the 2022 season. The Titans were upset at home by the New York Giants 21-20.

Let’s take a look at some key statistics and information about this matchup.

When is Tennessee Titans vs. Buffalo Bills Week 2? 

Date/Time: Sept. 19, 7:15 p.m. ET 
Arena: Highmark Stadium
How to watch: ESPN
Opening odds: Bills -9.5 | TEN +350, BUF -450 | O/U 49.5 

Week 2 Titans vs. Bills Betting Odds 

Here’s the latest point spread and total for Monday’s game.


Week 2 — Titans vs. Bills Stats to Know 

(Use the FTN Bets Prop Shop to find the best odds for player prop bets)

  • Tennessee upset Buffalo 34-31 as six-point underdogs in Week 6 last season — Derrick Henry ran for 143 yards and three touchdowns
  • Bills are 3-0-1 in the last four games as double-digit favorites 
  • Titans are 6-2 straight up and ATS in the last eight games as underdogs
  • Bills haven’t punted in four of the last six games, including the playoffs
  • Bills are second in both yards per play (7.1) and opponents’ yards per play (3.7)
  • Titans have given up a league-high 238 rushing yards on 7.4 yards per attempt
  • Josh Allen has 934 passing yards, 190 rushing yards and 13 total touchdowns in three games since the start of last year’s playoffs.
  • Ryan Tannehill has nine passing touchdowns and no interceptions in his last four games
  • Stefon Diggs had 122 receiving yards in Week 1 — he finished last season with eight straight games of fewer than 86 yards
  • Kyle Philips was Tennessee’s leading receiver with six receptions for 66 yards in Week 1
  • Devin Singletary had eight carries for 48 yards in Week 1 
  • Derrick Henry has at least 82 rushing yards in seven of his last eight games
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