San Francisco 49ers DVOA, Stats, & NFL Rankings

San Francisco 49ers running back Christian McCaffrey (knee) will not return to his team's outing against the Buffalo Bills on Sunday Night Football, per head coach Kyle Shanahan. The veteran RB was off to a hot start, averaging 7.4 yards per touch across his first seven handles for 53 rushing yards. He also caught two passes for 14 yards. However, he started awkwardly on a sweep and went down immediately and will not re-enter the game. Jordan Mason projects to handle most of the backfield touches for the remainder of the contest, with rookie running back Isaac Guerendo potentially mixing in as a change of pace. If Mason is available on your league's waiver wire, he'll be a priority addition going into Week 14. Given CMC's injury-riddled season, it would not be a surprise to see him miss the rest of the year, depending on the nature of his knee injury.

San Francisco 49ers running back Christian McCaffrey (knee) has exited Sunday night's contest against the Buffalo Bills with a knee injury and is questionable to return. McCaffrey took a toss on a 49ers first-and-ten, took a few steps, and immediately gave himself up as he did not look right. He was quickly brought into the blue medical tent for evaluation and escorted into the locker room shortly thereafter. It's unclear which play he picked up the injury in. Before his exit, the 28-year-old racked up 53 yards on his seven carries, adding another 14 through the air on 2-of-3 receiving. Stay tuned.

Los Angeles Rams wide receiver Demarcus Robinson (hand) had two catches for 49 yards in Sunday's win over the New Orleans Saints. Although two catches wouldn't mean anything to fantasy managers, one of them at least resulted in a trip to the end zone. Despite Puka Nacua and Cooper Kupp healthy and available, Robinson has been involved, catching a touchdown in each of his last two appearances. He suffered a hand injury in this one, so his status for the Week 14 matchup with the visiting Bills is up in the air. But if Robinson can play, he deserves flex consideration based on his contributions of late.

San Francisco 49ers quarterback Brock Purdy (shoulder) will play in Sunday's matchup versus the Bills. The signal-caller missed the Week 12 meeting with the Green Bay Packers. However, after practicing in full on Friday, he'll shed his questionable designation and be out there in Week 13 on Sunday night. Purdy is a capable fantasy quarterback, but with unfavorable weather conditions in Buffalo, he could have a tough time getting anything going in his return to action, meaning both teams may need to rely more on the run.

According to ESPN's Adam Schefter, San Francisco 49ers quarterback Brock Purdy (shoulder) is anticipated to play in Sunday night's matchup versus the Bills. The signal-caller wasn't on the field for the Week 12 loss to the Packers. As a result, Brandon Allen got the start, finishing with 199 yards, one touchdown, and one pick off 17-for-29 passing. If Purdy is officially cleared to suit up on Sunday, he could have a tough time getting it going, considering heavy snow is in the forecast for Buffalo. Still, he should at least be considered a starting fantasy option in multi-QB setups. But if Purdy isn't out there, Allen doesn't have much upside in any format.