San Francisco 49ers DVOA, Stats, & NFL Rankings

San Francisco 49ers quarterback Brock Purdy is in Miami for a Week 16 contest against the Dolphins. In Week 15's Thursday night game with San Francisco clinging to playoff hopes against the Rams, Purdy did not play well, completing 14-of-31 passes for 142 yards, no touchdowns, an interception, and three yards rushing. The weather in Miami is expected to be mild and dry, which is ideal for Purdy as he has struggled mightily in precipitation, but that's where the good news ends. Jalen Ramsey and the Dolphins' pass defense have allowed the NFL's fewest fantasy points per game to quarterbacks (13.4). Purdy is the 12th-ranked fantasy quarterback in points per game this season, and projections this week are congruent with that number. Consider Purdy a suboptimal play on the QB1/QB2 fence for the fantasy playoffs.

According to Matt Maiocco of NBC Bay Area, San Francisco 49ers running back Isaac Guerendo (hamstring) has been ruled out for Sunday's match against the Miami Dolphins. Guerendo was unable to participate in any team practices this week. He entered his Week 14 game with a foot injury and then left it with a hamstring concern. Fantasy managers should closely monitor his status next week as he may be in danger of missing more time. As a result, fantasy managers should expect Patrick Taylor Jr. to lead a depleted San Francisco backfield on Sunday. Throughout the season, he has tallied 50 yards on 14 attempts and brought in one of his two targets for 12 yards. Taylor should be viewed as a high-floor flex option this weekend facing a Miami rushing defense that has allowed the 12th-most PPR points to opposing RBs this season.

San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is dealing with a hamstring injury and is unlikely to play in Week 16 versus the hosting Miami Dolphins at Hard Rock Stadium on Sunday, according to a source. The Niners' backfield has just been decimated by injuries this year, with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring) already out for the season. Guerendo handled himself nicely as the starting RB for San Fran the last two games, carrying the ball 31 times for 135 yards (4.35 yards per carry) and two touchdowns while catching all six of his targets for another 68 yards. Fantasy managers won't have him available for semifinal matchups this week, though, with Patrick Taylor Jr. likely sharing rushing attempts with receiver Deebo Samuel Sr. against Miami. Israel Abanikanda will also likely be available as a backup. Taylor will be an RB3/flex, at best, in fantasy.

San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is not taking part in Wednesday's practice due to a hamstring injury. The rookie out of Louisville did not practice on Wednesday or Thursday last week due to a foot injury, so it appears he picked up a new ailment in last Thursday's loss to the Los Angeles Rams. Guerendo handled 100% of the team's running back touches (20) last week, but another injury could result in Patrick Taylor Jr. entering the fantasy football radar. Fantasy managers counting on Guerendo should pick up Taylor as an insurance policy for the fantasy football playoffs. The Dolphins present a neutral matchup for fantasy running backs, so whoever gets the start could have RB1 upside in Kyle Shanahan's offense.

Jacksonville Jaguars quarterback Mac Jones had a solid statistical outing in a 32-25 loss to the New York Jets. The former Patriot hadn't thrown a touchdown in any of his previous three starts, but that changed this week with a first quarter and fourth quarter passing touchdown to rookie Brian Thomas Jr. Jones finished with 31 completions on 46 attempts with two passing touchdowns but two interceptions. Jones has been struggling with turnovers, but at least moved the offense pretty well, which to be fair is more of a big deal in real football than in fantasy football. Along with Thomas Jr., Jones heavily relied on backup tight end Brenton Strange, who caught 11 passes for 73 yards. Jones will look to continue improving in Week 16 against the Las Vegas Raiders.