San Francisco 49ers DVOA, Stats, & NFL Rankings

San Francisco 49ers quarterback Brock Purdy is in Miami for a Week 16 contest against the Dolphins. In Week 15's Thursday night game with San Francisco clinging to playoff hopes against the Rams, Purdy did not play well, completing 14-of-31 passes for 142 yards, no touchdowns, an interception, and three yards rushing. The weather in Miami is expected to be mild and dry, which is ideal for Purdy as he has struggled mightily in precipitation, but that's where the good news ends. Jalen Ramsey and the Dolphins' pass defense have allowed the NFL's fewest fantasy points per game to quarterbacks (13.4). Purdy is the 12th-ranked fantasy quarterback in points per game this season, and projections this week are congruent with that number. Consider Purdy a suboptimal play on the QB1/QB2 fence for the fantasy playoffs.

According to Matt Maiocco of NBC Bay Area, San Francisco 49ers running back Isaac Guerendo (hamstring) has been ruled out for Sunday's match against the Miami Dolphins. Guerendo was unable to participate in any team practices this week. He entered his Week 14 game with a foot injury and then left it with a hamstring concern. Fantasy managers should closely monitor his status next week as he may be in danger of missing more time. As a result, fantasy managers should expect Patrick Taylor Jr. to lead a depleted San Francisco backfield on Sunday. Throughout the season, he has tallied 50 yards on 14 attempts and brought in one of his two targets for 12 yards. Taylor should be viewed as a high-floor flex option this weekend facing a Miami rushing defense that has allowed the 12th-most PPR points to opposing RBs this season.

San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is dealing with a hamstring injury and is unlikely to play in Week 16 versus the hosting Miami Dolphins at Hard Rock Stadium on Sunday, according to a source. The Niners' backfield has just been decimated by injuries this year, with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring) already out for the season. Guerendo handled himself nicely as the starting RB for San Fran the last two games, carrying the ball 31 times for 135 yards (4.35 yards per carry) and two touchdowns while catching all six of his targets for another 68 yards. Fantasy managers won't have him available for semifinal matchups this week, though, with Patrick Taylor Jr. likely sharing rushing attempts with receiver Deebo Samuel Sr. against Miami. Israel Abanikanda will also likely be available as a backup. Taylor will be an RB3/flex, at best, in fantasy.

San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is not taking part in Wednesday's practice due to a hamstring injury. The rookie out of Louisville did not practice on Wednesday or Thursday last week due to a foot injury, so it appears he picked up a new ailment in last Thursday's loss to the Los Angeles Rams. Guerendo handled 100% of the team's running back touches (20) last week, but another injury could result in Patrick Taylor Jr. entering the fantasy football radar. Fantasy managers counting on Guerendo should pick up Taylor as an insurance policy for the fantasy football playoffs. The Dolphins present a neutral matchup for fantasy running backs, so whoever gets the start could have RB1 upside in Kyle Shanahan's offense.

San Francisco 49ers wide receiver Deebo Samuel Sr. had his woes continue during a 12-6 home loss to the Los Angeles Rams on Thursday night. The frustrated former Gamecock caught three of seven targets for 16 yards and took two carries for three yards. Not every unfulfilled target was Samuel Sr.'s fault, but one certainly was. With the game tied midway through the third quarter on a 3rd-and-10 just outside the red zone, Samuel Sr. dropped a wide-open pass on a crossing pattern which would have been a certain first down, and perhaps a touchdown. It doesn't get much cringier than that after he complained about his usage on social media early in the week. Samuel Sr. will carry an average of 4.7 half-PPR points over his last five games into a matchup in Week 16 versus one of the toughest defenses against wide receivers in Miami.