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San Francisco 49ers vs. Los Angeles Chargers – Week 10 Betting Preview

NFL Bets

The San Francisco 49ers will welcome in the Los Angeles Chargers in Week 10 for a Sunday night showdown between two Super Bowl hopefuls. The Niners are getting healthy on the defensive end and have a loaded cast of characters to support quarterback Jimmy Garoppolo on offense. If they can avoid the injury bug the rest of the year, they have a legitimate chance at a Super Bowl despite currently sitting in second place in their own division.


The Chargers, who also sit in second place in their division, have been bitten by the injury bug as well, particularly on offense. Star quarterback Justin Herbert has been without stud wideouts Keenan Allen and Mike Williams for a couple weeks now, so much of the load has fallen on Austin Ekeler’s shoulders. Luckily for Los Angeles, Ekeler has been up to the challenge and has helped keep the Chargers afloat at 5-3. They’ll need a balanced attack and a gritty defensive effort to keep up with the Niners as touchdown-underdogs, though.

When is 49ers vs. Chargers Week 10?

Date/Time: Sunday, Nov. 13, 8:20 p.m. ET
Stadium: Levi’s Stadium
How to Watch: NBC
Opening Odds: 49ers -4.5 | O/U 47.5

Week 10 49ers vs. Chargers Betting Odds

Here’s a look at the latest point spread and total for Sunday’s game.


Week 10 49ers vs. Chargers Stats to Know

  • The Chargers are 4-0 ATS this season on the road
  • The 49ers are 2-0 ATS this season as home favorites
  • Three of the last four 49ers games have gone over the total
  • Justin Herbert’s touchdown rate is 2.6% since Week 3 compared to his career 5.4% touchdown rate
  • Jimmy Garoppolo has thrown multiple touchdowns in four straight games
  • Austin Ekeler leads all running backs in targets, receptions and receiving yards
  • In his last game, Christian McCaffrey became the first player since 2005 to run, catch and throw a touchdown in the same game
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