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San Francisco 49ers vs. Kansas City Chiefs – Week 7 Betting Preview

NFL Bets

The San Francisco 49ers will host the Kansas City Chiefs Sunday afternoon in what’s expected to be one of the most compelling games of the Week 7 slate. 


The 49ers will head back home after getting surprisingly trounced by the Falcons in Atlanta in Week 6. The Niners attempted to help themselves after the loss by trading for All-Pro running back Christian McCaffrey. Now, they’ll look to pick off a Chiefs team fresh off a loss.

In Week 6, the Chiefs stumbled at home to the Buffalo Bills in a matchup of AFC juggernauts, and things won’t get any easier when they travel to the Bay area as short road favorites. 

When is San Francisco 49ers vs. Kansas City Chiefs Week 7?

Date/Time: Sunday, Oct. 23, 4:25 p.m. ET
Stadium: Levi’s Stadium
How to Watch: FOX
Opening Odds: Chiefs -1 | O/U 47.5

Week 7 49ers vs. Chiefs Betting Odds

Here’s a look at the latest point spread and total for Sunday’s game.


Week 7 49ers vs. Chiefs Stats to Know

  • The Chiefs are 2-1 ATS on the road this season
  • The Chiefs have failed to cover the spread each of the last two weeks
  • The 49ers are 2-0 ATS at home this season
  • The total has gone UNDER in five of six 49ers games this season
  • Patrick Mahomes’ yardage prop is set at 288.5 passing yards – he’s failed to reach that number in each of his last two road games
  • Jimmy Garoppolo’s touchdown prop is set at 1.5 passing touchdowns – he’s thrown two touchdowns each of his last two games
  • Travis Kelce has had a touchdown or 100 yards in every game except one this season
  • Deebo Samuel’s rushing prop is set at 17.5 yards – he has gone under that number in four consecutive weeks
  • George Kittle’s targets, receptions and receiving yards have increased each of the last three weeks
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