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Pittsburgh Steelers vs. Buffalo Bills – Week 5 Betting Preview

NFL Bets

The Pittsburgh Steelers are the biggest betting underdogs of the 2022 NFL season for their matchup with the Buffalo Bills in Week 5. After making a change at quarterback, the Steelers are getting two touchdowns on the road against the Super Bowl favorites.


Kenny Pickett is expected to make his first start for a Pittsburgh team that hasn’t won since the season opener. Josh Allen and the Bills are tied for the best record in the conference. The Steelers did manage to defeat Buffalo a season ago, but a win for Pittsburgh in Week 5 would be a massive upset. 

Let’s take a look at some key statistics and information about this matchup.

When is Pittsburgh Steelers vs. Buffalo Bills Week 5? 

Date/Time: Oct. 9, 1 p.m. ET 
Arena: Highmark Stadium
How to watch: CBS 
Opening odds: Bills -14 | PIT +575, BUF -800 | O/U 47

Week 5 Steelers vs. Bills Betting Odds 

Here’s the latest point spread and total for Sunday’s game.


Week 5 — Steelers vs. Bills Stats to Know 

(Use the FTN Bets Prop Shop to find the best odds for player prop bets)

  • Steelers have lost three straight games straight up and ATS
  • Bills are 2-1-1 ATS and undefeated against teams that have fewer than three wins
  • Steelers are 2-2 to the over
  • Bills are 1-3 to the over 
  • Steelers haven’t scored more than 20 points in regulation 
  • Bills are third in yards per game (412.5) and fifth in points per game (28.5)
  • Steelers are 30th in both yards per game (278.8) and yards per play (4.8)
  • Bills are tied for first in yards per game allowed (234.5) and second in both opponents’ yards per play (4.2) and points per game (14.5)
  • Steelers and Bills are tied for most interceptions (7)
  • Josh Allen is second in passing yards per game (306.8)
  • Kenny Pickett has 120 passing yards and three interceptions on 13 attempts 
  • Stefon Diggs is second in receiving yards per game (101.5)
  • Diontae Johnson has at least 55 receiving yards in three of four games
  • Devin Singletary has fewer than 50 rushing yards in all four games
  • Najee Harris is averaging 50.5 rushing yards per game
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