Portland Trail Blazers guard Anfernee Simons (illness) is questionable ahead of Wednesday's matchup against the Dallas Mavericks. The 24-year-old has been under the weather. However, the questionable designation is at least a step in the right direction. At any rate, if Simons misses his fourth consecutive game on Wednesday night, Scoot Henderson or Malcolm Brogdon could remain in the starting lineup, although one of them will head back to the bench if Shaedon Sharpe is off a minutes restriction.

Los Angeles Lakers guard D'Angelo Russell (tailbone) isn't expected to play on Wednesday versus the Miami Heat. He's battling a tailbone contusion, so he'll miss a second straight game if he can't get healthy. Head coach Darvin Ham recently sent Russell to the bench, meaning his fantasy ceiling has been significantly lower of late. However, his absence could at least allow guys like Max Christie and Christian Wood to get a few extra minutes, although both men aren't dependable fantasy options.

Miami Heat forward Jimmy Butler (foot) remains out on Wednesday versus the Lakers. The veteran didn't suit up on Monday against the Clippers due to a foot injury suffered on Saturday in Utah. Butler has averaged 21.0 points, 5.0 rebounds, 4.5 assists, and 1.0 steals this season. However, he's battled various ailments during the 2023-24 campaign, and Wednesday will mark his sixth absence in Miami's previous seven games. The Heat also could be without Josh Richardson (back) and Caleb Martin (ankle), meaning Jamal Cain could remain in the starting lineup, although the 24-year-old had just nine points in 35 minutes against the Clippers.

Indiana Pacers guard Andrew Nembhard (back) is questionable ahead of Wednesday's matchup with the Milwaukee Bucks. The 23-year-old logged only eight minutes in Monday's meeting with Milwaukee before exiting with a back injury. As a result, Bennedict Mathurin and T.J. McConnell received extra work, with both men combining for 41 points. With Bruce Brown (knee) also uncertain for Wednesday's game, McConnell and Mathurin could remain more involved if Nembhard isn't available, giving them streaming value in deeper formats.

Milwaukee Bucks forward Khris Middleton (knee, wrist) is questionable for Wednesday's Central Division outing with the Indiana Pacers. The Bucks will head to San Antonio to meet the Spurs on Thursday, so it wouldn't be surprising if Middleton is ruled out against Indiana. But either way, he'll likely sit out one of those contests. Without Middleton on the floor, Andre Jackson Jr. or MarJon Beauchamp could enter the starting lineup, with the latter being a safer fantasy option. However, Middleton's absence will mean more scoring chances for Giannis Antetokounmpo and Damian Lillard.