Pittsburgh Pirates outfielder Andrew McCutchen is not in the starting lineup for Wednesday's contest against the Milwaukee Brewers and right-hander Bryse Wilson. The veteran homered as part of a two-hit effort on Tuesday but will give way to Connor Joe to leadoff and man left field on Wednesday. Interestingly, McCutchen's splits lean heavily towards righties so far this season as he's hitting .295 with all three of his homers coming off of southpaws while he is just 1-for-16 (.063) with three walks in 20 plate appearances against lefties. He is seeing semi-regular playing time this season, appearing in 16 of the team's 24 games but isn't doing a ton for fantasy managers with a .233 average and 30.9% K% on the young season.

Baltimore Orioles infielder Jackson Holliday is once again taking a seat against a left-handed starter on Wednesday as the team takes on the Los Angeles Angels and southpaw Tyler Anderson. Holliday has yet to start against same-handed pitching as the rookie gets his feet wet in the big leagues at just 20 years of age. It's been a very slow start out of the gate for the top prospect in baseball as Holliday is hitting just .059 (2-for-34) and is without an extra-base hit across his first 36 big-league plate appearances. Fantasy managers shouldn't hit the panic button yet as any investment in the 2022 first-overall pick should have been for the long haul, although it's not difficult to see the O's send him down to the minors for more seasoning if his immense struggles in the big leagues continue.

San Francisco Giants outfielder Jung Hoo Lee is out of the starting lineup on Wednesday afternoon with New York Mets left-hander Sean Manaea toeing the rubber. The lefty-swinging outfielder has been getting regular playing time out of the leadoff spot for the club this season but will take a seat as the Giants stack right-handed bats against Manaea. It's been a solid start to the 25-year-old's big-league career as Lee is hitting .272 with two homers, two steals, and a tiny 8.7% K% across his first 103 trips to the plate. Lee had a history of elite strikeout and contact rates through a wildly successful seven-year run in the KBO. Austin Slater will handle leadoff duties as he often does against left-handed pitching. First baseman LaMonte Wade Jr. is also out on Wednesday against the lefty.

Milwaukee Brewers infield prospect Gregory Barrios signed out of Venezuela in early 2021. He has proven himself as a reliable hitter and defender, possessing the qualities needed to ascend through the minors. He's not a power hitter -- he has just one home run over 198 pro games -- but shows a decent understanding of the strike zone, puts the ball in play, runs the bases well, and demonstrates the glovework needed to carve out a significant career at shortstop. Last week, Barrios logged multiple hits in all five of his games. He ultimately went 13-for-18 during his big week, adding six extra-base hits, seven RBI, two walks, one strikeout, and one stolen base. The 20-year-old will need to spend a little more time at High-A before he's ready for a promotion, but Barrios is certainly a name to monitor.

Texas Rangers pitching prospect Winston Santos is a 22-year-old who signed out of the Dominican Republic in 2019. He gets good velocity behind his mid-90s fastball and has also shown the ability to harness his changeup for strikes and induce weak contact. However, he needs to focus on significant development for his slider. The offering is not an established pitch, and he would benefit greatly from rounding out his repertoire with a reliable third offering that generates movement. Last week, Santos made his third start of the season and showcased pure excellence. He tossed five shutout innings, allowing one hit and a pair of walks along the way. However, what stood out most were his 12 strikeouts, a clear reflection of his ability to get control of his top offerings and miss bats. If he can continue to pitch at a high level, he'll be knocking on the door of the majors early next year.