San Francisco 49ers vs. Seattle Seahawks – Week 2 Betting Preview

Week 1 of the 2022 NFL season has come and gone, and now we head into Week 2. One of the marquee games on the board this weekend is the 1-0 Seattle Seahawks heading to San Francisco to take on the 0-1 49ers. 

I expect a great game between these two NFC West rivals. The Seahawks showed they might be better than people expected in Week 1, while the 49ers need to prove they are still a playoff team. 

Let’s dive into some key statistics and information about this matchup.

When is 49ers vs. Seahawks Week 2?

Time: 4:05 p.m. ET
Arena: Levi Stadium, Santa Clara, Calif.
How to Watch: FOX
Opening Odds: SF-9.5| SF -420, SEA +330| O/U 42

Week 2 49ers vs. Seahawks Betting Odds

Here is an up-to-date look at the betting odds for this matchup

Week 2 — 49ers vs. Seahawks Stats to Know

(Use the FTN Bets Prop Shop to find the best odds for player prop bets)

• The 49ers are 0-1 against the spread on the season and 0-1 to the over 
• The Seahawks are 1-0 against the spread on the season and 0-1 to the over
• The Seahawks lead the all-time series 30-17
• The Seahawks went 2-0 against the 49ers in 2021
• San Francisco was 6-6 against NFC opponents in 2021
• The Seahawks were 4-8 against NFC opponents in 2021
• Seattle allowed 433 total yards in Week 1 but won
• Seattle accumulated just 253 total yards in Week 1
• San Francisco had more total yards (331) than the Bears (204) in a Week 1 loss
• The 49ers had two turnovers and forced just one in Week 1
• The Seahawks had one turnover and forced two in Week 1
• Seattle went 6-11 on third down and 0-1 on fourth down in Week 1
• The 49ers went 8-17 on third down and 0-2 on fourth down in Week 1
• The 49ers had more time of possession than the Bears in a Week 1 loss
• The Seahawks had less time of possession than the Broncos in a Week 1 win