Kansas City Chiefs vs. Los Angeles Chargers

The Los Angeles Chargers will take on the Kansas City Chiefs as they look to secure a 2-0 start within a division that projects to be ultra-competitive all season. The Chargers opened up with a tight home victory over the Raiders as 3.5-point home favorites, and the Chiefs demolished the Cardinals 44-21 in Arizona as 6-point road favorites.

Taking out the Chiefs in their own house is a tall task, but it may be even tougher than usual for Los Angeles, who will likely be without star receiver Keenan Allen (hamstring). In his absence, the Chargers will need Justin Herbert to operate the offense at a high level against a Kansas City defense that looked impressive in Week 1.

When is Kansas City Chiefs vs. Los Angeles Chargers Week 2?

Date/Time: Thursday, Sept. 15, 8:15 p.m. EST
Stadium: Arrowhead Stadium
How to Watch: Amazon Prime Video
Opening Odds: Chiefs -3 | O/U 52.5

Week 2 Chiefs vs. Chargers Betting Odds

Here’s a look at the latest point spread and total for Thursday’s game.

Week 2 Chiefs vs. Chargers Stats to Know

The Chargers and the Chiefs are 1-0 ATS and straight up in 2022
The Chargers are 3-1 ATS and straight up in their last four games as road underdogs
The Chiefs are 5-5 ATS in their last 10 games as home favorites
The Chargers won straight up against the Chiefs as road underdogs in 2021
The Chargers and Chiefs have split their last four matchups straight up
Justin Herbert’s O/U is 283.5 passing yards – he’s gone UNDER that number in four of his last six games
Patrick Mahomes’ O/U is 306.5 passing yards – he threw for 360 yards in Week 1 but has gone UNDER that number in six of his last eight games
Mike Williams averages 2.6 more receptions and 23 more yards per game without Keenan Allen in the lineup
Travis Kelce’s O/U is 78.5 receiving yards – he’s gone OVER that number in four straight games and had 121 yards in Week 1
Austin Ekeler’s O/U is 53.5 rushing yards – he’s gone OVER that number five of his last six games