Kansas City Chiefs vs. Arizona Cardinals – Week 1 Betting Preview

After blowing an 11-point lead in the AFC Championship game, the Kansas City Chiefs have retooled and again have their sights set on the Lombardi Trophy. They open the season as favorites against the Arizona Cardinals, where they’ll take on a team that’s looking to put offseason drama behind them and compete for a playoff spot in a weak NFC. 

When is Arizona Cardinals vs. Kansas City Chiefs Week 1?

Date/Time: Sunday, Sept. 11, 4:25 p.m. ET
Stadium: State Farm Stadium
How to Watch: CBS, Paramount+
Opening Odds: Chiefs -3 | O/U 53

Week 1 Cardinals vs. Chiefs Betting Odds

Here’s a look at the latest point spread and total for Sunday’s game.

Opening Odds – Cardinals vs. Chiefs

When sportsbooks first released betting lines in May, the Chiefs were just field-goal-favorites over the Cardinals, but that number has since crept as high as six points. Despite trading Tyreek Hill in the offseason, many believe the Chiefs could have a more balanced offensive attack than in years past. The Cardinals open the year without DeAndre Hopkins who’s suspended for violating the league’s PED policy, but some bettors might still prefer Arizona, a team that proved to be more than scrappy as an underdog last season.

Bettors who like to dabble in totals will see the highest total of any game in Week 1. The O/U opened at 53 and has climbed as high as 54 in the months leading up to the season.

Week 1 Chargers vs. Raiders Stats to Know

• Cardinals did not play a single game as a home underdog last season
• Cardinals are 2-6 ATS in their last eight home games
• Cardinals were 6-0 straight up and ATS as underdogs last season
• Chiefs are 4-4 ATS in their last eight games as road favorites
• The over is 3-3 in the Cardinals’ last six games as underdogs
• The over is 5-0 in the Chiefs’ last five regular season games as favorites
• Patrick Mahomes’ O/U is 291.5 passing yards – he has failed to eclipse that number in 6 of his last 7 regular season games
• Kyler Murray’s O/U is 261.5 passing yards – he’s gone under that number in 5 of his last 7 games
• Travis Kelce’s O/U is 75.5 receiving yards – he went over that number in each of his last 3 games
• James Conner’s O/U is 48.5 rushing yards – he’s gone over that number in 8 of his last 16 games