Arizona Cardinals vs. Las Vegas Raiders – Week 2 Betting Preview

The Las Vegas Raiders host the Arizona Cardinals in a Week 2 matchup between a pair of winless teams. The betting odds indicate that the Raiders should pick up their first victory in their home opener.

The Cardinals were defeated by the Kansas City Chiefs 44-21 in their home opener, suffering the worst loss of any team in Week 1. The Raiders had their chances to win in Week 1 but came up short in a 24-19 road loss against the Los Angeles Chargers.

When is Arizona Cardinals vs. Las Vegas Raiders Week 2? 

Date/Time: Sept. 18, 4:25 p.m. ET 
Arena: Allegiant Stadium 
How to watch: CBS
Opening odds: Raiders -3.5 | AZ +160, LAV -190 | O/U 51.5 

Week 2 Cardinals vs. Raiders Betting Odds 

Here’s the latest point spread and total for Sunday’s game.

Opening Odds — Cardinals vs. Raiders 

The Raiders opened as 3.5-point favorites, though the line quickly increased to 5.5 points. Expectations are not high for the Cardinals, which seem to have picked up where they left off a season ago. DeAndre Hopkins is out for his second of six games due to a performance-enhancing drug suspension. 

The total is one of the few on the Week 2 schedule that is north of 50. Arizona gave up the most points in Week 1. Kyler Murray has engineered a top-eight offense in each of the last two seasons. Derek Carr threw three interceptions in the first game of the season.

Let’s take a look at some key statistics and information about this matchup.

Week 2 — Cardinals vs. Raiders Stats to Know 

(Use the FTN Bets Prop Shop to find the best odds for player prop bets)

• Cardinals have lost six of their last seven games, including the playoffs
• Raiders are 2-2 straight up and ATS in the last four games as home favorites 
• Cardinals are 6-0 straight up and ATS in the last six games as road underdogs
• Four of the last five Raiders’ games have gone under the total
• Raiders’ over/under is 29.5 points – Cardinals gave up a league-high 44 points in the opener 
• Kyler Murray is averaging 239.6 passing yards with a 1-4 record in the last five games without DeAndre Hopkins
• Derek Carr has eight interceptions in his last six games, including at least one pick in five of those contests
• Davante Adams had 10 catches for 141 yards and a touchdown in his first game with Las Vegas
• Marquise Brown had four catches for 43 yards and a touchdown in his Arizona debut
• Josh Jacobs had 10 carries for 57 yards in Week 1
• James Conner has 16 rushing touchdowns in his last 14 games