Oklahoma City Thunder forward/center Chet Holmgren (ankle) could be unavailable for the first time this season on Wednesday against Denver, as he has landed on the injury report as questionable. The rising star is nursing a left ankle sprain. Jaylin Williams could get a massive workload without Holmgren on Wednesday, while the rest of the frontcourt will also be asked to step up, especially with Jalen Williams (ankle) already ruled out for the contest.

Oklahoma City Thunder guard Shai Gilgeous-Alexander (illness) is in danger of missing his second game of the campaign on Wednesday against Denver. The Thunder star is considered questionable with an illness. Josh Giddey is set to run the offense without Gilgeous-Alexander, while a number of bench players could contribute. The Thunder have multiple starters with questionable tags, and Jalen Williams (ankle) has been ruled out, along with Isaiah Joe (sternum).

Denver Nuggets center Nikola Jokic (back) is questionable for Wednesday's matchup against the Thunder. The reigning Finals MVP is dealing with lower back pain and might sit out only his second game of the season. Jokic's only previous absence came on Nov. 27 against the Clippers, when Denver completed a back-to-back. DeAndre Jordan got a start against his former team and had a big game with 21 points and 13 rebounds. It's unlikely he will repeat the effort on Wednesday if Jordan gets the call again.

Dallas Mavericks center Dereck Lively II (nose) won't play against the Timberwolves on Wednesday night. He got his nose broken Monday against the Magic and will miss the 12th game of his rookie campaign. Lively has been a starter for all but one of his games during his first year in the league. Maxi Kleber and Dwight Powell are set to split the center minutes on Wednesday, although they aren't very productive players, and fantasy managers can safely ignore them.

Dallas Mavericks guards Luka Doncic (ankle) and Kyrie Irving (thumb) won't play Wednesday against Minnesota. Doncic, who's had a massive workload lately, will sit out his first game since Jan. 15, while Irving will miss a fifth consecutive game. With Dante Exum (knee) also on the injury report as doubtful, the Mavericks backcourt could be very shorthanded on Wednesday. The trio of Jaden Hardy, Tim Hardaway Jr., and Josh Green should do most of the heavy lifting.