San Francisco Giants outfielder Heliot Ramos, who homered out of the fifth spot in the batting order on Opening Day on Thursday, is starting in left field and batting leadoff on Saturday against the Cincinnati Reds and left-hander Nick Lodolo at Great American Ball Park. Left-handed hitters Mike Yastrzemski and LaMonte Wade Jr. will start on the bench for this one with a southpaw on the mound. In addition to Ramos' two-run homer against the Reds on Thursday, he struck out three times. The 25-year-old Puerto Rican will be an everyday outfielder for the Giants in 2025 after he made his first All-Star team in 2024 by slashing .269/.322/.469 with a .792 OPS, 22 home runs, 72 RBI, six stolen bases and 54 runs scored in 121 games in his first full MLB season. Ramos will certainly be in play in DFS lineups in the leadoff spot. He's gone hitless in just two career at-bats versus Lodolo.

Pittsburgh Pirates outfielders Andrew McCutchen and Tommy Pham are not in Saturday's starting lineup. Instead, Bryan Reynolds will serve as the designated hitter, which will open right field for Jack Suwinski. With Pham sitting out, Ji-Hwan Bae will cover left field. Through the first two games of the season, McCutchen has gone 1-for-7 with a double, an RBI, and a walk. Pham has also had a modest output in the batter's box, going 1-for-8 at the plate. However, Pham has swiped a bag in each of the first two games and added a double. Last season, Suwinski posted a .182/.264/.324 slash line with nine home runs and nine stolen bases. Bae struggled across his brief 29-game stint in the majors last season, holding a .189 AVG. Neither player should be targeted in DFS facing Miami right-hander Valente Bellozo.

Tampa Bay Rays first baseman Curtis Mead is not in the starting nine on Saturday afternoon for the second game of their series against the Colorado Rockies. Mead got the nod in the series opener on Friday and even batted in the leadoff spot. Instead, facing right-handed pitcher Antonio Senzatela, the Rays will opt to have Jonathan Aranda cover first base and bat cleanup. Fantasy managers should continue to monitor Mead's status as he may only be in the lineup against southpaws. In the opener, he went 0-for-4 at the plate with two strikeouts. Mead was able to earn a spot on the Opening Day roster thanks to his impressive performance during camp when he posted a stellar .524 AVG. Given his potential to have a limited role, Mead should only be rostered in deeper 15+ team formats.

Baltimore Orioles first baseman Ryan Mountcastle and outfielder Tyler O'Neill will not play on Saturday against the Toronto Blue Jays. Both players were in the starting lineup for their first two contests. Instead, Ryan O'Hearn will cover first base and bat third, and Heston Kjerstad will cover right field and bat sixth. Mountcastle has gone 1-for-9 with a double over his first two games. O'Neill has enjoyed an impressive start to his Baltimore tenure as he has gone 3-for-6 with a long ball and four RBI. O'Hearn enjoyed great success against right-handers last summer as he posted a .264/.338/.439 slash line with 15 home runs. Kjerstad has flashed elite upside at times at Triple-A but has yet to see it translate to the big leagues. O'Hearn is worth a look in DFS, but Kjerstad carries more risk given his lack of consistent production.

Baltimore Orioles catcher Gary Sanchez will make his Orioles debut on Saturday afternoon against the Toronto Blue Jays. Sanchez was riding pine during the opening two games of the series but will make his first start as an Oriole behind the dish. As a result, Adley Rutschman will serve as the designated hitter. The Orioles signed Sanchez to a one-year $8.5 million contract in the winter. Last season, Sanchez appeared in 89 contests for the Milwaukee Brewers and posted a .220/.307/.392 slash line with seven doubles and 11 long balls. He generated a modest 10.5 percent barrel rate with a 44.5 percent hard-hit rate. Fantasy managers should expect Sanchez to continue to see a limited role in the Baltimore offense, operating as the No. 2 backstop. He should not be targeted in DFS this afternoon, facing Max Scherzer, who will make his Toronto debut.