Houston Astros first baseman Jon Singleton, outfielder Chas McCormick and catcher Yainer Diaz are all resting on Saturday against the visiting Minnesota Twins. Jose Abreu will start at first base and bat eighth, Mauricio Dubon will play left and hit seventh, and Victor Caratini will do the catching and fill out the nine-hole for Houston against Twins right-hander Joe Ryan. None of Houston's lineup replacements have a ton of DFS upside in the bottom third of the batting order against a tough pitcher. Now that Abreu is back from the minors, the 32-year-old lefty-hitting Singleton is going to find himself on the bench more often. In three games since returning to the big leagues, the struggling Abreu has two hits and an RBI in 10 plate appearances. The veteran slugger is now hitting just .111 (9-for-81) on the year and is still searching for his first homer.

Baltimore Orioles outfielder Cedric Mullins is retreating to the bench on Saturday against the visiting Tampa Bay Rays. Colton Cowser will slide over to center field and bat sixth, while Kyle Stowers mans left field and hits in the eight-hole against Rays right-hander Taj Bradley. Mullins is still useful for his speed on the basepaths -- he's swiped 11 bags in 52 games this year -- but he's hitting just .185 (30-for-162) with six home runs, 22 RBI and 22 runs scored in 175 plate appearances with a career-high 25.7% strikeout rate. If Mullins continues to struggle offensively, he'll find himself on the bench more often against right-handed pitching. Stowers has gotten some run in Mullins' expense and has capitalized by going 7-for-18 with three doubles and five RBI in his first 10 games in 2024.

Toronto Blue Jays relief pitcher Jordan Romano (elbow) was placed on the 15-day injured list with right-elbow inflammation on Saturday, June 1. In a corresponding move, Brendon Little was promoted from Triple-A. The closer has been dealing with soreness in his elbow since Wednesday of this week and will now be sidelined for an extended period. In addition, the 31-year-old battled a similar injury earlier in the spring, which delayed his start to the season. Romano has pitched only 13 innings this season to the tune of a poor 6.59 ERA, 1.46 WHIP, and 4:13 BB:K ratio. As a result, Yimi Garcia and Chad Green are both candidates to see the majority of save opportunities while Romano remains sidelined.

Arizona Diamondbacks outfielder Joc Pederson is not in Saturday's lineup as they are scheduled to face southpaw Sean Manaea. The 32-year-old has yet to make a start against a left-handed pitcher this season, and Saturday will continue this pattern. As a result, Ketal Marte will shift to the designated hitter spot and bat leadoff, which opens up second base for Blaze Alexander, who will bat in the eight-hole. Pederson has looked quite comfortable with his new club through the early part of the season with a .308/.406/.546 line. Pederson should be expected to return to the starting lineup on Sunday as the Mets will send out right-hander Tylor Megill. Ketel Marte is always worth consideration in DFS, and Blaze Alexander could be a nice value option as Sean Manaea enters Saturday with a 3.16 ERA and 1.29 WHIP.

Miami Marlins catcher Christian Bethancourt was placed on the bereavement list on Saturday and will be out of the lineup for the next three days. In a corresponding move, the Marlins promoted backstop Jhonny Pereda from Triple-A Jacksonville. Bethancourt has struggled through his first 31 games of the season, posting a .162/.208/.250 line with just one home run and three doubles. Nick Fortes is starting at catcher Saturday afternoon, batting in the nine-hole, and should be expected to see the majority of starts will Bethancourt is away. Fortes has posted a modest .173 AVG with two long balls across 41 games this season. Fortes is best to fade in DFS as he has struggled to show consistency this season and is projected to face Michael Lorenzen, who enters Saturday with a 3.35 ERA.