Kansas City Royals first baseman Vinnie Pasquantino is not in the starting lineup when the Royals continue a series against the Milwaukee Brewers on Tuesday evening. Pasquantino has been in the lineup for each of the first four games of the regular season. He was in danger of missing Opening Day due to a hamstring injury, but was able to recover in time. On Tuesday, the Royals will give Cavan Biggio the start at first base. Through his first four games, Pasquantino has held a .214/.333/.643 slash line with one double, one triple, and one long ball. He has tallied four RBI and held a 2:2 BB:K. Fantasy managers should expect Pasquantino to return to the starting nine on Wednesday when the Royals will face Milwaukee ace Freddy Peralta.

New York Yankees starting pitcher Clarke Schmidt (shoulder) completed a three-inning simulated game on Monday. Schmidt is set to throw again on Saturday. The 29-year-old opened the regular season on the 15-day injured list due to rotator cuff tendinitis. However, Schmidt appears to be increasing his workload and has yet to face any significant setbacks. Fantasy managers should continue to monitor his progression as he could embark on a rehab assignment soon, as he was initially targeting a return to the big leagues at the end of April. Last season, Schmidt logged 85 1/3 innings and held a solid 2.85 ERA with a 1.18 WHIP. He tallied strikeouts at a 26.3 percent rate but held a modest 8.5 percent walk rate. When he is cleared to return, Will Warren will likely shift to a bullpen role or move back to Triple-A to continue his development.

New York Mets starting pitcher Sean Manaea (oblique) is still having trouble with his oblique and received a platelet-rich plasma shot. He will be shut down for two weeks. As a result, Manaea will now be sidelined till at least the end of May. The southpaw has been dealing with this oblique injury since spring training. The 33-year-old began a throwing program and was targeting a return in late April. However, he has faced a setback and will now face a longer recovery process. Fantasy managers should continue to monitor his status as he could face an extended absence. Last season, Manaea held a solid 3.47 ERA with a 1.08 WHIP across his first campaign in Queens. After the All-Star break, the 33-year-old was quite productive, boasting a 0.94 WHIP across 85 1/3 innings of work. While Manaea remains sidelined, Griffin Canning should continue to see opportunities in the starting rotation.

The Pittsburgh Pirates have optioned relief pitcher David Bednar to Triple-A Indianapolis. In a corresponding move, the Pirates promoted right-handed pitching prospect Thomas Harrington to the major leagues and designated catcher Jason Delay for assignment. Bednar has had a difficult start to the 2025 season after having similar struggles in 2024. Through three appearances this season, Bednar has tallied just three outs and lost two games. He has earned one save and allowed four hits and three earned runs. Last season, the 30-year-old posted a 5.77 ERA with a 1.42 WHIP across 57 2/3 innings. He blew seven saves and took eight losses. Fantasy managers should monitor his production at Triple-A as he attempts to turn the corner. While he is in the minor leagues, Colin Holderman and Dennis Santana will likely see the majority of save opportunities.

Arizona Diamondbacks outfielder Jake McCarthy is back in the lineup on Tuesday against the Yankees. He'll bat seventh and man left field for Arizona. McCarthy has started the season 0-for-8 with a 0:2 BB:K, but has managed to pick up two RBI along the way. Much of his fantasy appeal comes from his ability to steal bases, and he's yet to log one of those so far in 2025. He and the D-backs will take on the Yanks' Will Warren who will be making his first start of 2025. The righty had shown some solid stuff in the spring, but also allowed 11 earned runs over his final three starts (11 1/3 IP), so he was also very hittable at times. McCarthy had a breakout campaign last season, slashing .285/.349/.400 with eight home runs and 25 stolen bases, and has a good shot to get going Tuesday against the 25-year-old hurler.