San Francisco 49ers vs. Los Angeles Rams – Week 4 Betting Preview

In Week 4, the San Francisco 49ers will host their division rival Los Angeles Rams as they look to avoid suffering two straight primetime losses early in the season.

Jimmy Garoppolo and the offense struggled against the Denver Broncos in Week 3, and welcoming in a Rams defense led by Aaron Donald won’t make things any easier. The Rams, on the other hand, skated by the Arizona Cardinals in their own sluggish offensive performance in Week 3. 

In recent years, Kyle Shanahan and the 49ers have had LA’s number, but the last time these teams squared off resulted in an NFC Championship victory for the Rams, who went on to win the Super Bowl. 

When is San Francisco 49ers vs. Los Angeles Rams Week 4?

Date/Time: Monday, Oct. 3, 8:15 p.m. ET
Stadium: Levi’s Stadium
How to Watch: ESPN
Opening Odds: 49ers -2.5 | O/U 49

Week 4 49ers vs. Rams Betting Odds

Here’s a look at the latest point spread and total for Sunday’s game.

Week 4 49ers vs. Rams Stats to Know

• The Rams have only been underdogs three times since the start of 2021, and they’ve gone 2-1 straight up and ATS
• The 49ers were 2-0 ATS and straight up against the Rams in the 2021 regular season
• Matthew Stafford’s O/U is 260.5 passing yards – he’s gone under that number in two of three games this season
• Jimmy Garoppolo’s O/U is 224.5 passing yards – he’s gone under that number in three of his last four starts
• Cooper Kupp’s O/U is 93.5 receiving yards – he’s gone over that number in 16 of his last 19 games
• Deebo Samuel’s O/U is 55.5 receiving yards – he’s gone over that number in six of Jimmy Garoppolo’s last eight starts