San Francisco 49ers

San Francisco 49ers quarterback Brock Purdy had his best fantasy day of the young season in a 27-24 loss to the Rams in Los Angeles on Sunday. He finished with 22 completions of 30 attempts for 292 yards, three touchdowns, no interceptions, and one fumble lost. Purdy also took 10 rushing attempts for 41 yards. San Francisco led the entire game -; save for the last two seconds -; largely propelled by Purdy's connection with receiver Jauan Jennings who caught all three of Purdy's touchdown passes and was his favorite and most productive target. The former seventh-rounder could have done even more for his team and fantasy managers but failed to see a wide-open Brandon Aiyuk streaking down the middle past the Rams' secondary in San Francisco's penultimate drive. Purdy and the Niners have a Week 4 home matchup against the New England Patriots next Sunday.

San Francisco 49ers running back Isaac Guerendo will handle kickoff returns in place of injured wide receiver Deebo Samuel Sr. (calf) in Week 3, according to Matt Barrows of The Athletic. Barrows notes that the majority of kickoffs in 2024 have resulted in touchbacks, but if the Rams attempt any kicks that are returnable, Guerendo will handle that duty. The 24-year-old rookie has seen minimal opportunities on offense this year, rushing just once while handling one percent of offensive snaps in Week 2. He's off the fantasy radar.

San Francisco 49ers tight end George Kittle (hamstring) has been ruled out ahead of Sunday's matchup against the Los Angeles Rams. The star tight end showed up on the injury on Thursday, putting his status for the Week 3 contest in doubt. The injury couldn't have come at the worst time for the 49ers, with Christian McCaffrey (calf/Achilles) and Deebo Samuel Sr. (calf) missing this week's game. Brock Purdy now must lean heavily on Brandon Aiyuk, Jauan Jennings, and Jordan Mason against Los Angeles. Fantasy players are left scrambling for a last-minute tight end replacement off the waiver wire. Unfortunately, Kittle's backup, Eric Saubert, isn't a variable replacement option in standard-size leagues.

San Francisco 49ers kicker Jake Moody is in Los Angeles this week to face the Rams. The former third-round pick struggled with accuracy and field-goal opportunities in 2023 but has been productive in the young season. He currently sits in a three-way tie with New Orleans' Blake Grupe and Pittsburgh's Chris Boswell behind leader Brandon Aubrey for the second-most fantasy points per game among kickers due to a career day in Week 1, when he hit six of six field goal attempts. Even without Deebo Samuel Sr. (calf), Christian McCaffrey (Achilles), and probably George Kittle (hamstring), the 49ers offense figures to spend a good amount of time in Rams territory. The Rams' defense appears to be vulnerable after allowing four touchdowns and two field goals to the Arizona Cardinals in Week 2. Moody is a Top-3 option on Sunday.

San Francisco 49ers tight end Eric Saubert is expected to step in for George Kittle when the team is in Los Angeles to face the Rams in Week 3. Saubert, 30, spent time with six other teams before signing with San Francisco this offseason. In Week 2, Saubert saw his snaps increase as Kittle experienced cramping throughout the afternoon. The journeyman caught two of two targets for 26 yards in that one. Saubert has only two career touchdowns and has never eclipsed the five catches for 36 yards he put up as a member of the Denver Broncos in Week 5 of 2023 versus the Indianapolis Colts. If anyone can take statistical advantage of Kittle's absence, it could just as easily be fullback Kyle Juszczyk, who sometimes runs routes out the tight end position and has shown adequate ball skills and awareness for modest production in fantasy. Both Saubert and Jusczcyk could contribute in DFS if angling for a touchdown at rock-bottom prices, but one can surely do better in redraft formats regardless of league size.