San Francisco 49ers

San Francisco 49ers wide receiver Deebo Samuel Sr. (calf) will not practice Wednesday after suffering a calf strain in Sunday's loss to the Vikings. Despite the injury, Samuel had a solid Week 2 performance, recording eight catches for 110 yards. While reports suggest Samuel could miss multiple weeks, no official word has been given, and the team has yet to place him on injured reserve. All signs point to Samuel missing the Week 3 matchup against the Los Angeles Rams, with his status listed as doubtful. In his absence, fantasy managers can consider 49ers wide receiver Jauan Jennings as a potential streaming option for Week 3.

With San Francisco 49ers wide receiver Deebo Samuel Sr. (calf) set to miss a couple of weeks with a calf strain, Brandon Aiyuk is now set up to serve as the team's WR1 heading into a divisional matchup in Week 3 against the Los Angeles Rams. Aiyuk played only 60% of the offensive snaps in the Week 1 win over the New York Jets after a lengthy contract hold-in during training camp this summer. He played 87% of the snaps in the Week 2 loss to the Minnesota Vikings, but through two games, Aiyuk has been a fantasy disappointment with six catches on 10 targets for 71 yards and no scores. Despite the poor start, fantasy managers need to keep the 26-year-old locked into starting lineups for Week 3 with Samuel sidelined. In addition to Aiyuk being more involved, receiver Jauan Jennings should operate as the WR2, while tight end George Kittle will also have a safer target floor for as long as Samuel is out.

San Francisco 49ers wide receiver Ricky Pearsall (chest) appears to be making progress in his recovery process. The rookie wideout is only a few weeks removed from being shot during a robbery attempt. Despite that, Pearsall has started training again as he prepares to get back on the football field. This is great news as Pearsall could be back on the field as early as Week 5. Head coach Kyle Shanahan has stated that Pearsall remains week-to-week. The expectation is that Pearsall could be immediately utilized once he's cleared to play football again. The 49ers are going to be without wide receiver Deebo Samuel Sr. (calf) for at least a couple of weeks. His absence means an increased usage for Brandon Aiyuk, Jauan Jennings, and probably tight end George Kittle. Pearsall should be in the mix as well, but remains out until at least Week 5.

San Francisco 49ers wide receiver Deebo Samuel Sr. (calf) suffered a calf strain in the Week 2 loss to the Minnesota Vikings on Sunday and will be forced to miss a couple of weeks. It comes as a surprise after Samuel had eight catches (10 targets) for 110 receiving yards while also carrying the ball twice for 10 yards. With both Samuel and All-Pro running back Christian McCaffrey (Achilles, calf) out for the foreseeable future, San Fran's offense could struggle to put up points heading into a Week 3 divisional matchup against the Los Angeles Rams. Jauan Jennings should step into the WR2 role behind Brandon Aiyuk, who has been slow out of the gates after a lengthy contract hold-in, while tight end George Kittle's fantasy ceiling and floor will now be raised. Samuel's injury makes running back Jordan Mason even more of a lock as a must-start in fantasy lineups going forward.

San Francisco 49ers tight end George Kittle was heavily involved in the team's offense in Week 2, but it wasn't enough to prevent a 23-17 loss to the Vikings in Minnesota. The 30-year-old posted seven receptions on eight targets for 76 yards and a touchdown. Kittle's seven-yard score came near the end of the second quarter with San Francisco down by 10, as Kittle took a middle screen near the line of scrimmage and zagged his way around and through defenders to break the plane. He had quarterback Brock Purdy's eye throughout this one, the eight targets second only to receiver Deebo Samuel's 10. Kittle's performance was good enough to grab at least a temporary hold on the overall TE1 spot this week, heading into Monday night's Falcons/Eagles matchup. Next up for Kittle is a road matchup in Los Angeles against the division-rival Rams on Sunday.