Indianapolis Colts Week 1 odds and betting picks


The Indianapolis Colts have lots of questions heading into the 2021 season, and they start at the quarterback position. If Carson Wentz returns to elite form, the Colts could compete for a Super Bowl, but if Wentz struggles as he did last year, the Colts could miss the playoffs altogether. 



Indianapolis Colts Week 1 odds

Date/Time: September 12, 1 p.m. ET
Arena: Lucas Oil Stadium
How to watch: Fox
Opening odds: Seahawks -2.5 | O/U 50 (DraftKings Sportsbook)

Super Bowl odds update – Indianapolis Colts

The latest Super Bowl odds for the Indianapolis Colts are at +3500 at DraftKings Sportsbook – Here is a look at the odds movement:

  • Week 1: +3500
  • Post-NFL Draft: +2500

Colts futures odds

A look at various futures markets for the Indianapolis Colts

Carson Wentz MVP odds

Carson Wentz’ MVP odds are around +3500 on most books, but thanks to the FTN Prop Shop, we know you can get it for +8000 on BetMGM. He is expected to play in Week 1, so this could be a very valuable bet to make right now. 

Colts to win the AFC South

The Colts are currently +150 to win the AFC South at DraftKings Sportsbook. The team’s biggest and only real competition in the division is the Tennessee Titans, so if you think the Colts are winning more games this season, this bet is a value. 

Indianapolis Colts betting trends

The Colts’ odds this year took a hit when Wentz got hurt in the preseason and it was announced he could miss up to 12 weeks. Now, however, it looks more and more likely that Wentz will suit up for Week 1. As a result, if you’re high on the Colts, now is the time to pull the trigger on some bets before the books adjust to Wentz being healthy. 

Colts betting picks – NFL Week 1

The Colts face the Seahawks this week. Here is our full betting breakdown for the game.

Indianapolis Colts best bets

Below are the FTNBets picks against the total and spread, per the breakdown.

  • Spread: Seahawks -2.5 (FanDuel Sportsbook, -110)
    • You can also get Seahawks -3 at +100 on PointsBet, which offers more value if you think that this will be a blowout.
  • Total: no bet

For more information, betting picks, and analysis, check out the FTN NFL Bet Tracker.

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How to bet on this game

If you want to bet on this matchup and don’t already have a sportsbook account setup, check out FTNBets’ top sportsbook page. You can see what shops are available in your state while also comparing lines, odds, promotions and bonuses to ensure you get the best value for your investment.

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