Toronto Blue Jays outfielder Nathan Lukes will make his first start of the season on Friday against the visiting Baltimore Orioles and right-hander Charlie Morton at Rogers Centre. Lukes will be in center field and will bat eighth in the lineup with Ernie Clement starting on the bench. George Springer, who started in center field in the Opening Day loss, will shift to right field in this one. With Daulton Varsho (shoulder) starting the season on the injured list, the 30-year-old Lukes is expected to see plenty of playing time in center field against right-handed pitchers. In his second MLB season in 2024, he saw action in only 22 games and hit .303/.371/.447 with a homer, 10 RBI, one steal and 13 runs scored for the Jays. There isn't much pop in his bat, though, and Luke won't have much DFS appeal in his first 2025 start while batting out of the eight-hole in Toronto.

Baltimore Orioles infielder Jorge Mateo (elbow) will make his 2025 debut on Friday against the division-rival Toronto Blue Jays and right-hander Kevin Gausman, starting at shortstop and batting ninth. Jackson Holliday, who started at the 6 on Opening Day on Thursday, will slide back over to second base, with Ramon Urias starting on the bench. Jordan Westburg will start at third base and bat third. Mateo, 29, only played in five spring training games after having UCL reconstruction on his left (non-throwing) elbow in the offseason, and he went 1-for-11 with an RBI, two walks and five strikeouts in Grapefruit League play. He entered Thursday's Opening Day win over Toronto as a defensive replacement but didn't make a plate appearance. Given his lack of spring action and the fact he's hit .125 in eight career at-bats against Gausman, Mateo is one to avoid in DFS lineups on Friday.

Athletics outfielder Seth Brown will make the start in left field and will hit sixth on Friday against the division-rival Seattle Mariners and right-hander Luis Castillo at T-Mobile Park. Miguel Andujar, who made the start in left on Opening Day on Thursday, will retreat to the bench. Brown is expected to find himself on the A's bench more often than not in 2025, but he has hit .333 with a 1.012 OPS and a solo home run in 15 career at-bats against Castillo. The former 19th-round pick in 2015 out of Lewis-Clark State College is worthy of a bench spot for outfield in deep AL-only leagues, at best. The 32-year-old veteran lefty swinger hit .231/.283/.379 with a .662 OPS, 14 home runs and 44 RBI in his 124 games for the A's a season ago. We wouldn't recommend Brown for DFS lineups on Friday.

Arizona Diamondbacks outfielder Alex Thomas will make the start in center field over Jake McCarthy on Friday in the second game of the season against the visiting Chicago Cubs and right-hander Jameson Taillon at Chase Field. Thomas will bat seventh in the lineup. Thomas comes into 2025 looking to bounce back after a very disappointing 2024 campaign in which he played in only 39 games at the big-league level due to injuries and poor performance. In 103 plate appearances for Arizona, the 24-year-old left-handed hitter went just 18-for-95 (.189) with three home runs, 17 RBI and four stolen bases. Defense has been his calling card so far early in his career, but with a likely platoon role in Arizona's outfield this year, it's hard to get excited about him as anything more than outfield depth in NL-only leagues. Thomas is hitless in only two career at-bats against Taillon.

Arizona Diamondbacks catcher Gabriel Moreno will retreat to the bench in the second game of the season on Friday against the visiting Chicago Cubs. Backup Jose Herrera will make the start behind the dish and will bat ninth against Cubs right-hander Jameson Taillon at Chase Field. Moreno had a nice Opening Day showing in the loss on Thursday, going 2-for-3 with a walk and two runs scored. The 25-year-old should be back in the lineup on Saturday. Herrera, 28, hit .227/.290/.320 with a career-best .609 OPS, his first career home run and 13 RBI in 42 games played for the D-backs in his third year with the team in 2024 as a backup catcher. He's a defense-first catcher and should be avoided in DFS lineups on Friday. Herrera has never faced Taillon in his career.