Pittsburgh Pirates outfielder/designated hitter Andrew McCutchen and first baseman Rowdy Tellez are out of the lineup on Wednesday for the series finale against the hosting San Diego Padres at Petco Park. Catcher Joey Bart is serving as the designated hitter and batting cleanup, while Connor Joe will start at first and bat third against Padres left-hander Martin Perez. Yasmani Grandal is behind the dish and is hitting eighth. Fantasy managers will be said to see the 37-year-old McCutchen sitting, as he's opened the month of August by going 10-for-27 (.370) with three homers, a double, nine RBI and six runs scored in eight games. It's not a big surprise that Tellez is riding pine, as he's only seen 38 plate appearances this year against left-handed pitching, going 6-for-33 (.182) with two of his nine homers on the season.

Pittsburgh Pirates shortstop Oneil Cruz is taking the day off at Petco Park on Wednesday in the series finale against the hosting San Diego Padres. Cruz will be replaced at shortstop by Isiah Kiner-Falefa, who is batting leadoff against veteran left-hander Martin Perez. Although he's hit only one home run in 10 August games, Cruz is batting .395 (15-for-38) during the month and has added three doubles, five RBI and three stolen bases in the month. The 6-foot-7, 215-pound Dominican has one of the fastest bat speeds in the big leagues and is a must-start in fantasy lineups when he's active. Kiner-Falefa has hit .238 (10-for-42) with two doubles and two triples in 10 games since joining the Bucs at the trade deadline and will be an interesting DFS play in the leadoff spot. He's hit .286 against Perez in seven career at-bats.

Texas Rangers right-hander Dane Dunning will make the start on Wednesday versus the hosting Boston Red Sox at Fenway Park in the series finale. Dunning opened the year in Texas' starting rotation but then got hurt. His last eight appearances for the Rangers have come out of the bullpen, and he hasn't started a game since June 16 against the Seattle Mariners, when he gave up two earned runs in 4 2/3 innings in a loss. The 29-year-old did go four innings in relief on Aug. 6 versus the Houston Astros, but fantasy managers shouldn't expect him to go deep enough in Wednesday's start to qualify for a win. The matchup in Boston isn't a great one, either, and Dunning has been pretty mediocre overall with a 4-7 record, 4.77 ERA, 1.41 WHIP and 78 strikeouts in 77 1/3 innings in 2024 over 20 outings (12 starts). You should be able to find better streaming options in fantasy.

Colorado Rockies outfielders Charlie Blackmon and Jake Cave will head to the bench on Wednesday in the series finale against the hosting Arizona Diamondbacks at Chase Field with a left-handed pitcher on the mound. Hunter Goodman is serving as the designated hitter and is batting sixth, rookie Jordan Beck is in left and hitting seventh, and Sam Hilliard draws the start in right and is in the eight-hole against D-backs lefty Jordan Montgomery. Blackmon hasn't been terrible against southpaws this year, hitting .267 (20-for-75), but only one of his seven home runs on the year have come against them. Goodman is hitting just .182 (28-for-154) in his second year in the big leagues, but he has some DFS sleeper appeal because of his power (eight homers in 53 games).

Colorado Rockies catcher Elias Diaz is getting a breather on Wednesday for the series finale against the hosting division-rival Arizona Diamondbacks at Chase Field. Jacob Stallings is doing the catching and will bat cleanup for Colorado versus Diamondbacks left-hander Jordan Montgomery. Diaz is hitting a solid .270 (82-for-304) in 84 games this year for the Rockies, but his power has notably been down. After clubbing 14 long balls in 141 games in his first All-Star season in 2023, he has only five this year while driving in 36 in 327 plate appearances. Stallings, meanwhile, is one homer shy of tying his career-high in homers with eight as Colorado's backup. Five of his seven long balls in 2024 have come against left-handers, too, while hitting .300 (18-for-60) against them. Stallings isn't a bad DFS sleeper at the position against Montgomery.