Best MLB Bets Today – Thursday, May 22, 2025

FTN Staff
Each game is given an Indexed Fantasy Value based on the fantasy value of all individual players on the team.
One thing to note: There’s a lot of really good games to stack in 2025, and very few complete duds. There’s going to be a ton of unique stack opportunities that are all viable this season – which, in my opinion, is way more fun than in previous years.
Rank | Game | Fantasy-Relevant Players | Indexed Fantasy Value (100 = Average) | Quick Notes |
1 | DET @ MIN | 12 | 150 | Can we get a hell yeah? Dome game, too. Just need JJ to be good. |
2 | PHI @ BUF | 12 | 137 | Weather is obviously a risk in Buffalo in December, but this game is loaded for fantasy. |
3 | ARZ @ CIN | 12 | 135 | Weather a risk, but tons of fantasy firepower – especially if Marvin Harrison Jr. steps up. |
4 | LAR @ ATL | 10 | 129 | Dome game! Michael Penix Jr. is the wild card here. But good fantasy players at every position. |
5 | TB @ MIA | 14 | 116 | Very real shootout possibility, but which Dolphins will we get: The 2023 version or the 2024 version? |
6 | CHI @ SF | 14 | 114 | Could easily become the #1 game if CMC returns to form and Caleb Williams breaks out. |
7 | BAL @ GB | 13 | 104 | There are so many good games to stack it’s hard to believe this one ranks seventh. The ball is spread really well on both offenses, which makes it a little harder to hit but more rewarding if it does. |
8 | DAL @ WAS | 12 | 104 | Weather is a possible factor. Divisional rivalry games are sometimes ugly. But certainly has shootout potential. |
9 | HOU @ LAC | 13 | 100 | In a dome. Pretty tight target distribution – not difficult to stack. |
10 | NYG @ LV | 9 | 100 | Very few fantasy-relevant players – but those that are relevant are #good. Tough to stack the three biggest names, though. |
11 | DEN @ KC | 12 | 92 | It feels weird to say, but KC’s offensive “firepower” is actually what’s holding this game back. |
12 | JAX @ IND | 14 | 87 | This has potential if Anthony Richardson Sr. can make a big leap. |
13 | SEA @ CAR | 11 | 70 | Could end in a 13-10 snoozefest. |
14 | NE @ NYJ | 12 | 67 | I mean … maybe if Drake Maye is awesome? Hard pass on a game stack here, though. |
15 | PIT @ CLE | 9 | 51 | Good luck if you stack this one. |
16 | NO @ TEN | 8 | 44 | Super duper good luck if you stack this one. |