San Francisco 49ers

San Francisco 49ers running back Elijah Mitchell led the team in carries and rushing yards in Sunday's 21-20 home loss to the Los Angeles Rams. With All-Pro Christian McCaffrey inactive, Mitchell outcarried fellow backup Jordan Mason 14 to 6 and outgained him in rushing yards, 52 to 36. He also added two receptions on two targets for 15 yards. Mitchell finishes the year with 75 carries for 281 yards and two touchdowns. Barring any unexpected roster moves, Mitchell is likely to reprise his role as McCaffrey's backup in 2024 and remain a popular fantasy stash and handcuff for McCaffrey managers.

San Francisco 49ers tight end George Kittle (back spasms) and linebacker Dre Greenlaw (Achilles) have both been ruled out for the remainder of Week 18 versus the Los Angeles Rams. Both players were technically active this week but will not play. Neither player was in full uniform as Sunday's game kicked off. None of this news comes as a surprise given that San Francisco has clinched the NFC's No. 1 seed and has no reason to jeopardize the health of its key starters. Charlie Woerner will step up as the Niners' top tight end while Dee Winters takes over at weakside linebacker. Neither of them are on the fantasy radar.

San Francisco 49ers wide receiver Ray-Ray McCloud III (rib) and fullback Kyle Juszczyk (illness) are active for Week 18 versus the Los Angeles Rams. Both players had been listed as questionable. McCloud was limited in practice all week long, while Juszczyk was a late addition on Saturday. Fantasy managers shouldn't rely on either player this Sunday, though McCloud could sneak onto the fantasy radar if the 49ers limit snaps for Brandon Aiyuk and Deebo Samuel.

San Francisco 49ers wide receivers Jauan Jennings (concussion) and Danny Gray (shoulder) are inactive for Sunday's game against the Los Angeles Rams. Both players had been listed as questionable. Jennings was limited in all three practices this past week but will ultimately miss his third consecutive game. Meanwhile, Gray has been on injured reserve since August, and while it seemed like there was a chance he could play this week, that won't be the case. Both Jennings and Gray could return for the playoffs, but they would merely occupy depth roles.

San Francisco 49ers quarterback Brock Purdy (coach's decision) is inactive for Week 18 versus the Los Angeles Rams. This was widely expected given that San Francisco has already secured the NFC's No. 1 seed and home-field advantage through the conference championship. Sam Darnold should start in place of Purdy, who will be joined on the sideline by star running back Christian McCaffrey (calf). As of now, Brandon Aiyuk, Deebo Samuel, and George Kittle are expected to play but could have limited roles in order to preserve their health.