San Francisco 49ers DVOA, Stats, & NFL Rankings

San Francisco 49ers running back Christian McCaffrey (Achilles, calf) will remain on Injured Reserve and will not be available to make his 2024 debut this Thursday night against the division-rival Seattle Seahawks on the road in Week 6. McCaffrey is dealing with Achilles tendinitis in both of his legs and has yet to play so far in 2024. However, he did do some on-field work last week and didn't have any setbacks to his legs. The 49ers will continue to take things slow with last year's leading rusher, but it's been reported that CMC could be ready to make his season debut at the earliest in Week 7 for a rematch of last year's Super Bowl against the Kansas City Chiefs. But there's also a possibility that San Fran decides to hold McCaffrey out through their Week 9 bye. He needs to remain stashed in all fantasy formats, while Jordan Mason maintains RB1 status for however long McCaffrey is sidelined.

The San Francisco 49ers are not opening the practice window for rookie wide receiver Ricky Pearsall (chest) this week because the team isn't going to have a full-speed practice this week as they prepare to take on the division-rival Seattle Seahawks on a quick turnaround to kick off Week 6 action on Thursday night at Lumen Field. Head coach Kyle Shanahan said Pearsall will continue to undergo physical therapy while he stays on the Non-Football Injury list. Pearsall sustained a gunshot wound to his chest on Aug. 31 during an armed-robbery attempt and he also missed the majority of training camp due to a hamstring injury. The 24-year-old is getting close to rejoining practices, but the Niners will likely take the full 21-day window before activating him from the NFI list. Pearsall is fighting an uphill battle to make an impact in redraft fantasy leagues in 2024 after already missing a lot of time.

Los Angeles Rams wide receiver Demarcus Robinson was the lone pass-catcher to find the end zone in the 24-19 loss to the Green Bay Packers on Sunday. He finished the game with three receptions for 28 yards and a score on five targets. In terms of target share, Robinson was fourth in line after Colby Parkinson, Jordan Whittington, and Tutu Atwell all saw double-digit targets. Robinson at least salvaged a bit of fantasy scoring with his touchdown for any of the fantasy managers who needed his services. The Rams move into their bye week next, which may be enough time for Cooper Kupp (ankle) to return in Week 7, which would lower Robinson's fantasy ceiling.

San Francisco 49ers tight end George Kittle continued his hot streak by putting up 16.4 half-PPR points on Sunday, but it wasn't enough to avoid a 24-23 home loss to the Arizona Cardinals. The colorful former Hawkeye hauled in eight of a co-team-high 12 targets for 64 yards and a touchdown. Kittle's day could have been even better if he had caught a tough first-quarter red-zone target and avoided an unforced drop on a 14-yard target later on. Historically, Kittle has been boom-or-bust but his fantasy production has been steady this year, averaging 13 half-PPR points per game with a low of six points, which came in Week 1. Kittle will be a top choice at tight end in Week 6 when the 49ers face the Seahawks in Seattle on Thursday Night Football.

San Francisco 49ers wide receiver Jauan Jennings came back down to earth in a 24-23 home loss to the Arizona Cardinals on Sunday. San Francisco's third wide receiver finished with one reception of four targets for 13 yards receiving. Jennings left briefly in the first quarter with an apparent hand injury. Although he returned quickly, he could be seen on the game broadcast in discomfort even after his return. On the bright side, three of his targets took place in the end zone just before the half and he got more attention overall from Brock Purdy than Deebo Samuel Sr. did. While Jennings has certainly broken out this year as a factor in fantasy, he'll likely be touchdown-dependent as a deep-league FLEX option if San Francisco's other pass-catchers remain healthy. Jennings gets the Seahawks at Lumen Field in a Week 6 Thursday night matchup.