San Francisco 49ers DVOA, Stats, & NFL Rankings

San Francisco 49ers quarterback Brock Purdy faces the division-rival Seahawks in Seattle for a Week 6 matchup on Thursday night. In a surprising one-point home loss to the Arizona Cardinals last week, Purdy left something to be desired with a 19-for-35, 244-yard effort, including a touchdown, two interceptions, and 33 yards rushing. Seattle is 11th-best in the NFL at limiting fantasy quarterbacks in Yahoo default scoring. However, the Seahawks are dealing with significant injuries on defense, which boosts Purdy's outlook. Starting defenders CB Riq Woolen, DT Byron Murphy II, and LB Uchenna Nwosu have all been ruled out, plus two linebackers and a safety have been tagged questionable. Running back Christian McCaffrey (Achilles/calf) remains on Injured Reserve, but Purdy is otherwise equipped with a fully healthy offense. He'll look to beat projections for just the second time this year as a mid/low QB1.

San Francisco 49ers tight end George Kittle (ribs) is good to go on Thursday night, according to Tom Pelissero of the NFL Network. Kittle was a limited participant during the first two practice sessions of the week but was able to upgrade to full participation on Wednesday. The 31-year-old should be locked into all starting lineups as he faces a Seattle defense that has allowed the 19th-most points to opposing tight ends. Kittle has found the end zone in each of the past three games he has played in and averaged 61.7 yards and 6.3 receptions during this span. He should be viewed as a TE1 and should also be considered as a solid flex option in all DFS formats on Thursday evening.

San Francisco 49ers head coach Kyle Shanahan said he's not sure how long kicker Jake Moody's right high-ankle sprain will take to heal but that it would be "about a month." Moody injured his right ankle in the Week 5 loss to the division-rival Arizona Cardinals on Sunday and could be a candidate to land on Injured Reserve, which would keep him sidelined for at least four games. In the meantime, the Niners signed veteran kicker Matthew Wright to handle the kicking, and he could be a decent streaming candidate in a strong 49ers offense. Fantasy managers using Moody through the first five weeks will obviously need to pivot moving forward. It's a tough blow for fantasy managers, as Moody was the No. 2 kicker in fantasy points through the first five weeks. If Moody were to go on IR, he wouldn't be eligible to return until Week 12 against the Seattle Seahawks.

San Francisco 49ers tight end George Kittle (ribs) was listed as a limited participant in practice for the second straight day this week on Tuesday. Kittle missed the Week 3 contest with a hamstring injury but returned in Week 4, only to suffer an injury to his ribs. He played through his rib injury in the Week 5 loss to the division-rival Arizona Cardinals and caught a season-high eight passes (12 targets) for 64 yards and a touchdown. Kittle will most likely be removed from the final Week 6 injury report on Wednesday and be fine to play on Thursday night against the division-rival Seattle Seahawks, where he'll be a must-start TE1 in fantasy. Despite missing Week 3 due to injury, Kittle has managed to find paydirt in each of the last three games that he's played in, going for 19 catches and 185 yards on 24 targets.

San Francisco 49ers tight end George Kittle (ribs) is still listed on the team's injury report on a short week with a divisional matchup coming on Thursday night on the road at Lumen Field against the Seattle Seahawks. Although the Niners didn't practice on Monday, they listed Kittle as limited on their estimated practice report. Kittle suffered a rib injury in Week 4 but played through the injury in the Week 5 loss to the division-rival Arizona Cardinals and was no worse for the wear, catching eight pass on 12 targets for 64 yards and a touchdown. The 30-year-old missed Week 3 with a hamstring injury but has caught a touchdown pass in each of his last three games. He should be fine to suit up this Thursday and will be a must-start TE1 for fantasy managers after seeing a season-high 12 targets against the Cardinals.