San Francisco 49ers DVOA, Stats, & NFL Rankings

San Francisco 49ers rookie running back Isaac Guerendo filled in nicely for starter Jordan Mason (shoulder) in a Week 6 36-24 victory versus the Seattle Seahawks at Lumen Field. Mason left the game with an apparent shoulder injury in the second quarter and came back in for one carry just after the half, never to return. Guerendo did most of the replacement work, finishing with 10 carries for 99 yards. He was not targeted in the passing game. Though Guerendo looked competent overall, it's worth noting that the bulk of his yardage came on a fourth-quarter 76-yard run that salted the game away for San Francisco. He may have scored on the play but appeared to pull up at the last second to allow the 49ers to work more clock. Guerendo will be a top waiver target heading into Week 7 against Kansas City if Mason is sidelined, but it's worth noting that fourth-year back Patrick Taylor Jr. was involved as well, with five carries and a target of his own in Mason's absence.

San Francisco 49ers quarterback Brock Purdy led the team to a 36-24 victory on Thursday night in Seattle. The 24-year-old completed 18 of 28 attempts for 255 yards, three touchdowns, and no turnovers. He added four rushing attempts for 19 yards. Purdy looked much better this week on the road than he did at home against Arizona in Week 5, especially in avoiding the pass rush. He was not sacked, avoiding the batted balls and mid-throw arm obstructions that have caused some of his recent turnovers. Purdy is now 4-0 against the Seahawks in his career, including playoffs. He'll have plenty of time to rest up before a Week 7 marquee matchup at home against the Chiefs.

San Francisco 49ers rookie first-round wide receiver Ricky Pearsall (chest) will resume practicing next week. Pearsall might have had his practice window opened this week if not for a quick turnaround with a Thursday night tilt in Week 6 against the division-rival Seattle Seahawks. The 24-year-old will instead return to practice next week, and the 49ers will have 21 days to activate him from the Non-Football Injury list. Pearsall missed a good chunk of time in training camp with a hamstring injury and then was shot in the chest during a robbery attempt right before the start of the regular season. It's great news that Pearsall is nearing a return to practice, but we'd expect the Niners to use the full 21-day window to get him up to speed. And when Pearsall does, he'll be battling for snaps behind Deebo Samuel Sr., Brandon Aiyuk and Jauan Jennings. Pearsall is a dynasty/keeper stash, at best.

San Francisco 49ers running back Christian McCaffrey (Achilles) is targeting an early November return from Injured Reserve. McCaffrey was technically eligible to come off IR to play on Thursday night in Week 6 against the Seattle Seahawks, but that was never going to happen. The fact that CMC has yet to practice means he still has a ways to go before he can even think about making his 2024 debut. Fantasy managers obviously can do nothing but hope McCaffrey returns sooner than later and keep him stashed in an IR spot. In the meantime, Jordan Mason, who has been one of the league's leading rushers through five weeks, will continue to serve as San Fran's lead back. Mason is the RB5 in half-PPR scoring heading into Thursday night's game against Seattle and should be deployed in all fantasy starting lineups against a beat-up defense.

San Francisco 49ers wide receiver Jauan Jennings will face the Seattle Seahawks at Lumen Field on Thursday night. In Week 5, Jennings fell back into his expected role after a huge fantasy performance in Week 3 as a replacement for an injured Deebo Samuel Sr. and securing the team lead in targets in Week 4. Against Arizona last week, Jennings posted one reception on four targets. On the bright side, three of those targets came while he was in the end zone. As exciting as Jennings has been, it was never realistic to think that Jennings would usurp a healthy Brandon Aiyuk, Deebo Samuel Sr., and George Kittle to maintain consistent fantasy relevance. Jennings will probably still mix in a touchdown here and there, but with the whole squad healthy, he should be kept on benches or in the free-agent pool outside of the deepest leagues in Week 6.