San Francisco 49ers DVOA, Stats, & NFL Rankings

The San Francisco 49ers won't open the practice window for running back Christian McCaffrey (Achilles) this week, according to head coach Kyle Shanahan. McCaffrey is ramping up his football activities as he deals with bi-lateral Achilles tendinitis in both of his legs, but he won't return to practice next week or be available to play in Week 7 for a Super Bowl rematch against the Kansas City Chiefs. CMC remains on Injured Reserve, and the 49ers are most likely targeting a potential return for last year's Offensive Player of the Year in Week 10 against the Tampa Bay Buccaneers after their Week 9 bye. Fantasy managers must remain patient and hope the 28-year-old can return to form quickly upon his return later this season. With Jordan Mason (shoulder) suffering an AC joint sprain in Thursday night's win over the Seahawks, rookie Isaac Guerendo could be called upon to start in Week 7 versus KC.

San Francisco 49ers tight end George Kittle amplified his dominance at the fantasy tight end position during a 36-24 Thursday night victory in Seattle. The two-time First-team All-Pro caught five of six targets for 58 yards and two touchdowns. Kittle now has five touchdowns in his last four games and is averaging 14.5 points per game in Yahoo default scoring, while second place is held by Dallas Goedert and Brock Bowers at 10.5. That's the widest margin between two consecutively ranked players in the entire tight-end landscape. Kittle has had similar stretches during his career and he's always been streaky, so fantasy managers who have been propelled by Kittle to early winning records may consider selling high to win-desperate teams. Kittle and the Niners will face the Kansas City Chiefs at home in a Week 7 Super Bowl LVIII rematch.

San Francisco 49ers wide receiver Jauan Jennings contributed modestly to a 36-24 victory over the Seahawks in Seattle on Thursday night. The former seventh-rounder caught three of five targets for 27 yards. While conventional wisdom held that Jennings would fade into the background after his monster performance in Week 3 upon the return of George Kittle and Deebo Samuel Sr. from injury, he has maintained more relevance in San Francisco's offense than expected. For example, Jennings has out-targeted Brandon Aiyuk in three of the past four weeks and has only one fewer reception than Deebo Samuel Sr. in the past three weeks. Still, Jennings will be a touchdown-dependent low-floor FLEX when the 49ers have their main pass-catchers healthy, including in a Week 7 rematch of Super Bowl LVIII against the Kansas City Chiefs at home.

San Francisco 49ers wide receiver Brandon Aiyuk fell back into his early-season fantasy slump during a 36-24 victory over the Seahawks in Seattle. He finished with two catches on four targets for 37 yards, and one other reception -- for a good chunk of yardage -- called back on a holding penalty. He is still searching for his first touchdown of 2024. Coming into the game as a consensus WR1, Aiyuk has now come in under projections in five of six contests. Quarterback Brock Purdy spread the ball around in this one, as Deebo Samuel Sr., George Kittle, and Jauan Jennings had six, five, and five targets respectively. With Aiyuk's underperformance stretching into October, Jennings' out-targeting of Aiyuk in the past three of four weeks should be acknowledged -- still, sell-low at your own risk. Aiyuk is fully capable of burning impatient fantasy players. San Francisco will need Aiyuk in a Week 7 Super Bowl LVIII rematch at home against the Kansas City Chiefs.

San Francisco 49ers rookie running back Isaac Guerendo filled in nicely for starter Jordan Mason (shoulder) in a Week 6 36-24 victory versus the Seattle Seahawks at Lumen Field. Mason left the game with an apparent shoulder injury in the second quarter and came back in for one carry just after the half, never to return. Guerendo did most of the replacement work, finishing with 10 carries for 99 yards. He was not targeted in the passing game. Though Guerendo looked competent overall, it's worth noting that the bulk of his yardage came on a fourth-quarter 76-yard run that salted the game away for San Francisco. He may have scored on the play but appeared to pull up at the last second to allow the 49ers to work more clock. Guerendo will be a top waiver target heading into Week 7 against Kansas City if Mason is sidelined, but it's worth noting that fourth-year back Patrick Taylor Jr. was involved as well, with five carries and a target of his own in Mason's absence.