San Francisco 49ers

San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is dealing with a hamstring injury and is unlikely to play in Week 16 versus the hosting Miami Dolphins at Hard Rock Stadium on Sunday, according to a source. The Niners' backfield has just been decimated by injuries this year, with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring) already out for the season. Guerendo handled himself nicely as the starting RB for San Fran the last two games, carrying the ball 31 times for 135 yards (4.35 yards per carry) and two touchdowns while catching all six of his targets for another 68 yards. Fantasy managers won't have him available for semifinal matchups this week, though, with Patrick Taylor Jr. likely sharing rushing attempts with receiver Deebo Samuel Sr. against Miami. Israel Abanikanda will also likely be available as a backup. Taylor will be an RB3/flex, at best, in fantasy.

San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is not taking part in Wednesday's practice due to a hamstring injury. The rookie out of Louisville did not practice on Wednesday or Thursday last week due to a foot injury, so it appears he picked up a new ailment in last Thursday's loss to the Los Angeles Rams. Guerendo handled 100% of the team's running back touches (20) last week, but another injury could result in Patrick Taylor Jr. entering the fantasy football radar. Fantasy managers counting on Guerendo should pick up Taylor as an insurance policy for the fantasy football playoffs. The Dolphins present a neutral matchup for fantasy running backs, so whoever gets the start could have RB1 upside in Kyle Shanahan's offense.

San Francisco 49ers wide receiver Deebo Samuel Sr. had his woes continue during a 12-6 home loss to the Los Angeles Rams on Thursday night. The frustrated former Gamecock caught three of seven targets for 16 yards and took two carries for three yards. Not every unfulfilled target was Samuel Sr.'s fault, but one certainly was. With the game tied midway through the third quarter on a 3rd-and-10 just outside the red zone, Samuel Sr. dropped a wide-open pass on a crossing pattern which would have been a certain first down, and perhaps a touchdown. It doesn't get much cringier than that after he complained about his usage on social media early in the week. Samuel Sr. will carry an average of 4.7 half-PPR points over his last five games into a matchup in Week 16 versus one of the toughest defenses against wide receivers in Miami.

San Francisco 49ers kicker Jake Moody went 2-for-2 on field goals during Week 15 against the Los Angeles Rams. His conversions came from 47 and 53 yards out, giving some fantasy managers yardage-based scoring boosts. Moody's six points represented the entirety of the Niners' scoring on Thursday Night Football as they fell to the Rams, 12-6. Although this was a frustrating outcome for San Francisco, it's promising to see that Moody's fantasy value can survive even when the offense struggles to find a rhythm. The 25-year-old now ranks 12th among kickers in fantasy points per game this year, making him a fringe option for managers heading into the 49ers' Week 16 battle against the Miami Dolphins.

San Francisco 49ers wide receiver Jauan Jennings caught just two of his nine targets against the Los Angeles Rams on Thursday, finishing Week 15 with 31 yards through the air. He managed to lead the team in targets while finishing second to George Kittle in receiving yards. Thursday's loss to the Rams was a rough showing for the Niners, who mustered just two field goals and zero touchdowns on primetime television. That led to a rare dud game from Jennings, who had not previously recorded fewer than nine fantasy points (PPR) since taking over as the de facto No. 1 wide receiver following Brandon Aiyuk's season-ending knee injury. Despite Thursday's frustrating performance, Jennings appears to still be the 49ers' No. 1 wide receiver as he continues to get more looks in the passing game than Deebo Samuel Sr. However, fantasy managers should proceed with caution ahead of next week's matchup against the Miami Dolphins, who have allowed the fewest fantasy points to opposing wide receivers in 2024.