San Francisco 49ers

San Francisco 49ers running back Isaac Guerendo (foot) "plans to play" in Thursday night's game against the Los Angeles Rams. According to Adam Schefter of ESPN, despite being listed as questionable, Guerendo "feels good" and "plans to play" on Thursday night. The 24-year-old suffered a foot sprain in last Sunday's win over the Chicago Bears. He was a limited participant in Wednesday's walkthrough and has a chance of playing on Thursday. Guerendo rushed for 78 yards and two touchdowns on 15 carries while catching two passes for 50 yards in the Week 14 win over the Bears. With the short week and Christian McCaffrey (knee) and Jordan Mason (ankle) on injured reserve, the 49ers might play it safe with Guerendo and rest him. If Guerendo can't suit up, Patrick Taylor Jr. is expected to handle most of the carries, while Israel Abanikanda and Ke'Shawn Vaughn will back him up. Fantasy managers will have to check back an hour before the 8:15 p.m. (ET) kickoff to ensure Guerendo is active before setting their lineups for the first week of the fantasy playoffs.

San Francisco 49ers kicker Jake Moody will kick off the NFL's Week 15 when the Los Angeles Rams come to town for Thursday Night Football. Last week in a 38-13 home victory over the Chicago Bears, Moody made his only field goal attempt, a 23-yarder in the second quarter. He made all five of his extra-point attempts. Los Angeles' defense hasn't been good, allowing the sixth-most yards in the NFL, but they are nearly equally bad at preventing touchdowns in the red zone. Even if San Francisco's offense is humming like last week, it could be another extra-point game for Moody. In addition, Moody has struggled with accuracy, posting a field goal percentage of 76.9, compared to a league-wide average of 83.5%. Moody is Rotoballer's 18th-ranked kicker in Week 15.

San Francisco 49ers tight end George Kittle will face the Los Angeles Rams at home in a Week 15 divisional matchup on Thursday night. Last week, Kittle rebounded from his worst performance of the season -; a one-catch night in Buffalo -; to a six-reception, 151-yard game at home in Week 14 versus Chicago. The gregarious University of Iowa product is having one of the best years of his career in 2024, ranking just behind Las Vegas rookie Brock Bowers in total fantasy points despite missing two games. Kittle has done a lot this year to shake his boom/bust reputation, as he's only failed to reach 10 half-PPR points twice this season. The Rams' pass defense hasn't been good overall, which holds true when isolating the tight end position. They have been the 12th-easiest matchup in the NFL to opposing tight ends despite not having to face Kittle in Week 3 when he was out with injury. Fantasy managers should lock Kittle into their lineups for the duration of the fantasy playoffs. In Week 15, he's a top-2 option.

San Francisco 49ers wide receiver Deebo Samuel Sr. gets his next chance to break out of a brutal slump when the team hosts the Los Angeles Rams on Thursday night. The former first-team All-Pro has averaged 3.3 half-PPR points per game over his last four contests. Samuel created drama early in the week, expressing dissatisfaction with a perceived decrease in the team getting him the ball. There is some truth to the complaint. Samuel's career-high was 8.5 touches per game in 2021, and he averaged 6.5 touches per game last year, compared to 6.0 touches this year. Of course, he didn't mention his season total of four broken tackles on social media, nor his 13.8 yards per reception (down almost a full yard from 2023), or his 2.9 yards per carry. The squeaky wheel may get the grease in this situation, but head coach Kyle Shanahan and quarterback Brock Purdy don't seem like the type to force-feed a complaining wideout based on their reactions. The Rams have been a top-10 matchup for opposing wideouts, but it will be hard to trust Samuel in fantasy playoff lineups. He's a back-end WR3, at best, in Week 15.

San Francisco 49ers wide receiver Jauan Jennings will line up against the division-rival Los Angeles Rams on Thursday night in Santa Clara. The former Tennessee Volunteer is coming off his second-best fantasy performance of the year, having caught seven of eight targets for 90 yards and two touchdowns at home against Chicago. The Rams are a good matchup for Jennings on paper, as they are tied with Cleveland as the seventh-most generous defense for fantasy wideout production. As the fantasy playoffs begin, Jennings is the overall WR14 in half-PPR scoring, including the games before Brandon Aiyuk (knee) was injured. Jennings should be considered a WR2 with a solid target floor in Week 15.