San Francisco 49ers

As expected, San Francisco 49ers running back Christian McCaffrey (calf) was officially back on the practice field on Tuesday as the team prepares for their Week 1 regular-season opener on Monday Night Football against the New York Jets. Even though a calf injury caused McCaffrey to miss most of training camp and all of the preseason, he was still the consensus No. 1 overall fantasy pick after leading the NFL with 1,459 rushing yards and 21 total touchdowns (14 rushing, seven receiving) in 16 regular-season games last year. CMC played in a combined 10 games due to injuries with the Carolina Panthers in 2020-21, but he's played in 33 regular-season contests the last two years and is the best fantasy player, hands down, when he's on the field. The 28-year-old is a must-start when active, but he'll certainly have more of a bust factor in Week 1 given all the time he missed in camp, especially with a tough matchup on tap.

San Francisco 49ers Pro Bowl running back Christian McCaffrey (calf), who has been sidelined with a strained calf for most of training camp, is anticipated to return to practice on Tuesday. Although the team won't release a detailed injury report on his participation until Thursday, his return to the field is a promising sign of his availability for the season opener. McCaffrey has been limited to side-field workouts in recent weeks, but it appears he can join team drills as the 49ers begin their Week 1 preparations. Injuries have been a concern for McCaffrey in the past; he played only 10 games combined during the 2020 and 2021 seasons with the Carolina Panthers. However, he has rebounded strongly, playing all 17 games in 2022 and 16 games last season. In 2023, McCaffrey led the NFL with 1,459 rushing yards, added 564 receiving yards, and scored 21 total touchdowns, earning him the Offensive Player of the Year award. While McCaffrey seems on track to be ready for Week 1, it's wise to draft his backup, Jordan Mason, as a precaution. Mason will become a must-start running back if McCaffrey misses any time.

San Francisco 49ers rookie first-round wide receiver Ricky Pearsall (shoulder, chest) is being placed on the reserve/Non-Football Injury list, meaning he will miss at least the first four games of the 2024 season. The rookie out of Florida is out of the hospital and is recovering from a gunshot wound he suffered on Saturday. Needless to say, this is a unique situation, and his recovery will be worth monitoring moving forward. When Pearsall does return to action, he's unlikely to be on the fantasy football radar, barring an injury to Deebo Samuel Sr., Brandon Aiyuk, or Jauan Jennings. Especially after the scary incident over the weekend, expectations should be tempered for Pearsall in Year 1, but he remains an interesting stash in dynasty leagues.

San Francisco 49ers running back Christian McCaffrey did not register a touch during the 2024 NFL preseason. Many teams choose to rest their stars, and McCaffrey certainly fits that description. He's healthy and ready to go ahead of the upcoming season. Undoubtedly the best running back in the NFL, McCaffrey is coming off the second RB1 finish of his career in fantasy football. He eclipsed 2,000 scrimmage yards for the second time in his career last season and delivered a 21-touchdown campaign, which was a career-high. As long as McCaffrey stays healthy, he's the favorite to lead all running backs in fantasy points.

San Francisco 49ers wide receiver Brandon Aiyuk recently agreed to a four-year, $120 million contract extension, which included $76 million guaranteed. Although ESPN's Adam Schefter reported that was the same deal that "had been on the table," ESPN's Jeremy Fowler stated Aiyuk's decision to sign was based on wanting to get on the field. "Aiyuk wanted to play in games," said Fowler while appearing on NFL Live. "He didn't want to sit out and hold out of that portion of it. And then he was comfortable with the contract." The 26-year-old appeared in 16 games for the Niners last season, amassing a career-high 1,342 receiving yards with 75 catches and seven touchdowns. Without question, the end of the lengthy contract dispute has already resulted in Aiyuk seeing more attention during fantasy drafts heading into the 49ers' Week 1 meeting with the New York Jets.