San Francisco 49ers

San Francisco 49ers wide receiver Ricky Pearsall caught just one of his four targets during Thursday's loss to the Los Angeles Rams, finishing Week 15 with 16 yards. The rookie pass-catcher has struggled to emerge as a relevant option in redraft leagues given his No. 3 role behind Deebo Samuel Sr. and Jauan Jennings. The 24-year-old has just 13 catches for 153 yards this year, and most of that production came in a singular game against the Tampa Bay Buccaneers back in Week 10. As long as Pearsall remains third on the depth chart, he should be benched or left on waivers in fantasy football. That trend continues next week against the Miami Dolphins, who have been quite stingy against opposing wide receivers in 2024.

San Francisco 49ers tight end George Kittle caught four of his seven targets for a team-best 61 yards during Thursday's loss to the Los Angeles Rams. Even as the 49ers struggled to mount scoring drives in this primetime divisional battle, Kittle found ways to get involved to salvage his fantasy performance. The 31-year-old now has double-digit fantasy points in point-per-reception scoring in 10 of his 12 games, ranking as the overall TE2 in fantasy football. He's on pace to have his second-best fantasy season ever, giving managers a major boost down the stretch and potentially helping them advance in the fantasy playoffs. Kittle should continue to be started in all leagues when the 49ers take on the Miami Dolphins in Week 16.

San Francisco 49ers rookie running back Isaac Guerendo was inefficient during a 12-6 loss to the Los Angeles Rams in Santa Clara on Thursday night. There was some question coming into the game about whether Guerendo -- who spent the week questionable with a foot injury -- could fulfill head coach Kyle Shanahan's typical bell cow usage. Guerendo answered those questions emphatically by taking 16 of San Francisco's 18 carries, but he struggled to make them count, finishing with 57 yards and no touchdowns. He also caught all four of his targets for 18 yards, keeping his night in line with fantasy projections in PPR leagues. Assuming no aggravation of his injury, the fourth-rounder will be in play for lineups in Week 16 versus the Dolphins in Miami, who have been a mildly favorable matchup for running backs this season.

San Francisco 49ers quarterback Brock Purdy never got much going during a deflating 12-6 home loss to the Los Angeles Rams on Thursday night. Purdy finished 14-for-31 for 142 yards, no touchdowns, and one interception. He scrambled once for three yards. While the Rams' secondary made more than a few nice plays on the ball, Purdy struggled with accuracy in this one. Bad throws may have been understandable during a rainy first half but they continued even after the rain had stopped. It's hard to trust Purdy as a fantasy asset moving forward, as he has now sandwiched a productive game between two week-killing games. Purdy-starting managers who somehow survive to see another round in the fantasy playoffs should consider quarterback shopping after this weekend, as he'll draw two tough matchups coming up. He'll get the Dolphins in Miami next week and the Lions at home in Week 17.

San Francisco 49ers rookie running back Isaac Guerendo (foot) is officially active for Thursday night's divisional clash in Week 15 versus the visiting Los Angeles Rams. Guerendo suffered a mild foot sprain in the first start of his career in the Week 14 blowout win over the Chicago Bears but will be active on a short week. Before hurting his foot on Sunday, Guerendo had 15 carries for 78 yards (5.2 yards per tote) and two rushing touchdowns, also catching both of his targets for 50 yards through the air. The 24-year-old sure looked good in the lead-back role for San Fran with both Christian McCaffrey (knee) and Jordan Mason (ankle) out. Guerendo will likely be the Niners' lead back the rest of the season, although he'll certainly come with more risk on Thursday night and could share more of the backfield work with Patrick Taylor Jr. Consider Guerendo a volume-based RB3/flex in Week 15.